2-oxoglutarate carboxylase

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2-oxoglutarate carboxylase
Identifiers
EC number 6.4.1.7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

In enzymology, a 2-oxoglutarate carboxylase (EC 6.4.1.7) is an enzyme that catalyzes the chemical reaction

ATP + 2-oxoglutarate + HCO3- ADP + phosphate + oxalosuccinate

The 3 substrates of this enzyme are ATP, 2-oxoglutarate, and HCO3-, whereas its 3 products are ADP, phosphate, and oxalosuccinate.

This enzyme belongs to the family of ligases, specifically those forming carbon-carbon bonds. The systematic name of this enzyme class is '. Other names in common use include oxalosuccinate synthetase', carboxylating factor for ICDH (incorrect), CFI, and OGC.

References[edit]

  • Aoshima M, Ishii M, Igarashi Y (2004). "A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 51 (3): 791–8. doi:10.1046/j.1365-2958.2003.03863.x. PMID 14731279. 
  • Aoshima M, Igarashi Y (2006). "A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6". Mol. Microbiol. 62 (3): 748–59. doi:10.1111/j.1365-2958.2006.05399.x. PMID 17076668.