The 2010–11 Telkom Knockout was a football (soccer) knockout competition which comprised the 16 teams in the South African Premier Soccer League. It was the 19th tournament, and the fifth under the Telkom Knockout name. The tournament is effectively South Africa's league cup, as entry is open only to clubs in the top league. The cup is usually played in the first half of the season. The tournament began on 23 October, and it ended on 4 December 2010. Kaizer Chiefs won their 9th title, by defeating Orlando Pirates 3–0 in the final at Soccer City.
In all matches there has to be a winner on the day, which will be decided if there is a winner after full-time (90 minutes). If teams are tied at full-time, then extra time is played; penalties will decide the winner if the scores are still even (there is no golden goal rule).