The 2010 Big 12 Championship Game was played at 7:00 p.m. on Saturday, December 4, 2010, at Cowboys Stadium in Arlington, Texas to determine the 2010football champion of the Big 12 Conference. At that time, it was the final championship game for the conference as two members of the Big 12 had announced their intentions to leave the conference. The South Division was represented by Oklahoma and the North Division was represented by Nebraska. Oklahoma defeated Nebraska 23-20 to win the final Big 12 Championship and claim their seventh Big 12 Title. It was Oklahoma's eighth appearance in the game.
From 2009 through 2013, the Big 12 Championship Game was scheduled to be played at Cowboys Stadium (now known as AT&T Stadium) in Arlington, Texas. During June 2010, however, Nebraska and Colorado announced that they would leave the Big 12 for other conferences in 2011. Because then-current NCAA rules required that a conference have 12 members in order to stage a football championship game that was exempt from the organization's limits on regular-season games, it was announced on September 30, 2010, that the Big 12 would no longer have a conference championship game, starting with the 2011 football season.
Following a January 2016 NCAA rule change that allows FBS conferences to conduct football championship games regardless of their membership numbers, the Big 12 announced that the championship game would be reinstated in 2017.