The 2010 Big 12 Championship Game was played at 7:00 p.m. on Saturday, December 4, 2010, at Cowboys Stadium in Arlington, Texas to determine the 2010football champion of the Big 12 Conference. It was the final championship game for the conference as two members of the Big 12 had announced their intentions to leave the Big 12. The South Division was represented by Oklahoma and the North Division was represented by Nebraska. Oklahoma defeated Nebraska 23-20 to win the final Big 12 Championship and claim their seventh Big 12 Title. It was Oklahoma's eighth appearance in the game.
From 2009 through 2013, the Big 12 Championship Game was scheduled to be played at Cowboys Stadium (now known as AT&T Stadium) in Arlington, Texas. During June 2010, however, Nebraska and Colorado announced that they would leave the Big 12 for other conferences in 2011. Because NCAA rules require that a conference have 12 members in order to stage a football championship game, it was announced on September 30, 2010, that the Big 12 would no longer have a conference championship game, starting with the 2011 football season.