The album entered the top five in Mexico and the top twenty in the United States. To promote the album, a video for the song "Un Grito en la Noche", previously a single from Guzmán's album Eternamente Bella (1990), was released in September 2011. The standard edition of the album in Mexico includes a DVD documentary about the recording sessions. 20 Años de Éxitos En Vivo con Moderatto received a platinum+gold certification in Mexico by the Asociación Mexicana de Productores de Fonogramas y Videogramas and garnered four nominations for the Premios Oye!, including Album of the Year.
Ten songs previously recorded by the singer are included: "Llama Por Favor", "Un Grito en la Noche" and the title track from her album Eternamente Bella of 1990. "Hacer El Amor Con Otro" and "Güera" are taken from Flor de Papel (1991). "Mala Hierba" and "Mírala, Míralo" were first included on Libre in 1993. "De Verdad" was the lead single from Soy (2001). "Volverte a Amar" from Indeleble in 2006. "Verano Peligroso" is the theme song of a film starred by Guzmán in 1991, and was first included on her compilation album Lo Más Prendido. The album is the first to feature the song "Día de Suerte", the theme song of the Mexican telenovelaUna Familia con Suerte. "Ya Lo Veía Venir" was the first single from Moderatto's 2008 album Queremos Rock. "No Te Lo Tomes Personal" is a new song written by Jay de la Cueva and Guzmán.
20 Años de Éxitos En Vivo con Moderatto was recorded on March 17, 2011 at Palacio de los Deportes in Mexico City. Guzmán was joined on stage by the Mexican band Moderatto, where they performed before a selected audience of fans. American singer Jenni Rivera accompanied the singer on the song "Eternamente Bella", while Puerto-Rican performer Vico C joined them on "Mala Hierba". Guzmán also presented the song "Día de Suerte" for the first time. Guzmán declared on her experience working with Moderatto: "On stage, when I'm with them, everything is magic. Right now I feel part of the band because it made me feel very happy and made me feel like their songs are mine." A long form music video was recorded and included on the standard Mexican edition of the album as an accompanying DVD. This music video opened in several movie theaters in the United States and Mexico, and tickets were available for free to her fans on her official website.
Guzmán received four nominations for the Premios Oye! for her work on the album, including Album of the Year and Female Pop Album, winning the latter.20 Años de Éxitos also earned a nomination for Rock Album of the Year at the Premio Lo Nuestro 2012.