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5E or 5-E can refer to:
- 5°E, or 5th meridian east, a longitude coordinate
- 5e, a type of Category 5 cable
- 5E, a learning cycle developed by Biological Sciences Curriculum Study.
- Astra 5°E, a communications satellite
- Dungeons & Dragons 5th edition, a fantasy tabletop role-playing game (RPG) released in 2014.
- F-5E, a model of Northrop F-5 jet
- Five Eyes, an espionage alliance between the US, UK, NZ, Canada, and Australia.
- Tropical Depression Five-E (2008)
- SGA Airlines (IATA airline code)
- 5E, the production code for the 1978–79 Doctor Who serial The Power of Kroll
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