Since this season, all the 16 teams of the Primera División would join the competition. All the rounds were played in a single-game format.
In the round of 16, the home team was designed by the luck of the draw, while in the quarterfinals, teams that have played the previous round away had preference to host the match.[2]
New entries: Clubs participating in Primera División gain entry. Opponents seeding: Teams playing the 2018–19 UEFA Women's Champions League could not face each other. Local team seeding: Luck of the draw. Knock-out tournament type: Single match.
Quarter-finals
13 Dec 2018
30 Jan 2019
4
8 → 4
Opponents seeding: Teams playing the 2018–19 UEFA Women's Champions League could not face each other. Local team seeding: Teams that played the round of 16 away. If both played it away, luck of the draw. Knock-out tournament type: Single match.
Semi-finals
4 Feb 2019
17 Feb 2019
2
4 → 2
Opponents seeding: Luck of the draw. Local team seeding: Luck of the draw. Knock-out tournament type: Single match.