DHRS4

DHRS4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3O4R
Identifiers
Aliases	DHRS4, CR, NRDR, PHCR, PSCD, SCAD-SRL, SDR-SRL, SDR25C1, SDR25C2, dehydrogenase/reductase (SDR family) member 4, dehydrogenase/reductase 4
External IDs	OMIM: 611596; MGI: 90169; HomoloGene: 49646; GeneCards: DHRS4; OMA:DHRS4 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	23,969,279 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	55,727,797 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; duodenum; ; human kidney; ; mucosa of transverse colon; ; monocyte; ; apex of heart; ; left adrenal cortex; ; left ventricle; ; gastrocnemius muscle; ; right adrenal cortex;
	Top expressed in
	right kidney; ; human kidney; ; proximal tubule; ; left lobe of liver; ; duodenum; ; gallbladder; ; submandibular gland; ; brown adipose tissue; ; Paneth cell; ; saccule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; alcohol dehydrogenase [NAD(P)+ activity]; signaling receptor binding; oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor; carbonyl reductase (NADPH) activity; 3-keto sterol reductase activity; NADP-retinol dehydrogenase activity;
Cellular component	peroxisomal membrane; peroxisome; extracellular exosome; endoplasmic reticulum membrane; mitochondrion; nucleus; peroxisomal matrix; cytosol;
Biological process	steroid metabolic process; alcohol metabolic process; protein tetramerization; cellular ketone metabolic process; retinol metabolic process; protein targeting to peroxisome;
	Sources:Amigo / QuickGO
Orthologs
	10901
	28200
	ENSG00000157326; ENSG00000284807
	ENSMUSG00000022210
	Q9BTZ2
	Q99LB2
NM_001282987; NM_001282988; NM_001282989; NM_001282990; NM_001282991;
	NM_021004
	NM_001037938; NM_030686
NP_001269916; NP_001269917; NP_001269918; NP_001269919; NP_001269920;
	NP_066284
	NP_001033027; NP_109611
	Wikidata
View/Edit Human	View/Edit Mouse

Dehydrogenase/reductase SDR family member 4 is an enzyme that in humans is encoded by the DHRS4 gene.^[5]^[6]^[7]

References

^ ^a ^b ^c ENSG00000284807 GRCh38: Ensembl release 89: ENSG00000157326, ENSG00000284807 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022210 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J. 340 ( Pt 2) (Pt 2): 561–8. doi:10.1042/bj3400561. PMC 1220285. PMID 10333503.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4".

Song XH, Liang B, Liu GF, et al. (2007). "Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma". Int. J. Cancer. 120 (8): 1618–26. doi:10.1002/ijc.22306. PMID 17230527.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Du J, Huang DY, Liu GF, et al. (2004). "CDNA cloning of a short isoform of human liver NADP (H) -dependent retinol dehydrogenase/reductase and analysis of its characteristics". Yi Chuan Xue Bao. 31 (7): 661–7. PMID 15473316.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

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[refGRCh38Ensembl-1] ENSG00000284807 GRCh38: Ensembl release 89: ENSG00000157326, ENSG00000284807 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022210 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10333503-5] Fransen M, Van Veldhoven PP, Subramani S (Jul 1999). "Identification of peroxisomal proteins by using M13 phage protein VI phage display: molecular evidence that mammalian peroxisomes contain a 2,4-dienoyl-CoA reductase". Biochem J. 340 ( Pt 2) (Pt 2): 561–8. doi:10.1042/bj3400561. PMC 1220285. PMID 10333503.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-7] "Entrez Gene: DHRS4 dehydrogenase/reductase (SDR family) member 4".

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References

Further reading