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DIP2A

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DIP2A
Identifiers
AliasesDIP2A, C21orf106, DIP2, disco interacting protein 2 homolog A
External IDsOMIM: 607711; MGI: 2385920; HomoloGene: 41012; GeneCards: DIP2A; OMA:DIP2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001081419

RefSeq (protein)

NP_001074888

Location (UCSC)Chr 21: 46.46 – 46.57 MbChr 10: 76.1 – 76.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Disco-interacting protein 2 homolog A is a protein that in humans is encoded by the DIP2A gene.[5]

Model organisms

Model organisms have been used in the study of DIP2A function. A conditional knockout mouse line called Dip2atm2b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[6] Male and female animals underwent a standardized phenotypic screen[7] to determine the effects of deletions.[8][9][10][11] Additional screens performed: - In-depth immunological phenotyping[12]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160305Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020231Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: DIP2A DIP2 disco-interacting protein 2 homolog A (Drosophila)".
  6. ^ Gerdin AK (2010). "The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. S2CID 85911512.
  7. ^ a b "International Mouse Phenotyping Consortium".
  8. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ^ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. S2CID 18872015.
  11. ^ White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Sanger Institute Mouse Genetics Project, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP (2013). "Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes". Cell. 154 (2): 452–64. doi:10.1016/j.cell.2013.06.022. PMC 3717207. PMID 23870131.
  12. ^ a b "Infection and Immunity Immunophenotyping (3i) Consortium".[permanent dead link]

Further reading