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Protein-coding gene in the species Homo sapiens
Importin subunit alpha-3 , also known as karyopherin subunit alpha-4 , is a protein that in humans is encoded by the KPNA4 gene .[ 5] [ 6]
The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen.[ 7]
KPNA4 has been shown to interact with RECQL [ 5] STAT3 .[ 8]
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