SEC63

SEC63
Identifiers
Aliases	SEC63, DNAJC23, ERdj2, PRO2507, SEC63L, SEC63 homolog, protein translocation regulator, PCLD2
External IDs	OMIM: 608648; MGI: 2155302; HomoloGene: 5220; GeneCards: SEC63; OMA:SEC63 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	107,958,208 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	42,708,510 bp
RNA expression pattern
	Top expressed in
	epithelium of colon; ; body of pancreas; ; parotid gland; ; stromal cell of endometrium; ; bone marrow cells; ; ganglionic eminence; ; ventricular zone; ; left ovary; ; olfactory zone of nasal mucosa; ; right ovary;
	Top expressed in
	seminal vesicula; ; parotid gland; ; lacrimal gland; ; neural layer of retina; ; saccule; ; ventricular zone; ; left lobe of liver; ; tail of embryo; ; otic placode; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding; signaling receptor activity;
Cellular component	endoplasmic reticulum membrane; cytosol; integral component of membrane; membrane; endoplasmic reticulum; Sec62/Sec63 complex;
Biological process	IRE1-mediated unfolded protein response; protein targeting to membrane; liver development; protein transport; SRP-dependent cotranslational protein targeting to membrane; multicellular organism aging; renal system development; nitrogen compound metabolic process; posttranslational protein targeting to endoplasmic reticulum membrane; posttranslational protein targeting to membrane, translocation; transport;
	Sources:Amigo / QuickGO
Orthologs
	11231
	140740
	ENSG00000025796
	ENSMUSG00000019802
	Q9UGP8
	Q8VHE0
	NM_007214; NM_018529
	NM_153055; NM_001359283; NM_001359284; NM_001359285; NM_001359286
	NP_009145
	NP_694695; NP_001346212; NP_001346213; NP_001346214; NP_001346215
	Wikidata
View/Edit Human	View/Edit Mouse

Translocation protein SEC63 homolog is a protein that in humans is encoded by the SEC63 gene.^[5]^[6]^[7]

Function

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER.^[7]

Clinical significance

Mutations of this gene have been linked with autosomal dominant polycystic liver disease.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000025796 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019802 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Woollatt E, Pine KA, Shine J, Sutherland GR, Iismaa TP (Jun 1999). "Human Sec63 endoplasmic reticulum membrane protein, map position 6q21". Chromosome Res. 7 (1): 77. doi:10.1023/A:1009283530544. PMID 10219736. S2CID 19417266.
^ Skowronek MH, Rotter M, Haas IG (Nov 1999). "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog". Biol Chem. 380 (9): 1133–8. doi:10.1515/BC.1999.142. PMID 10543453. S2CID 46726981.
^ ^a ^b "Entrez Gene: SEC63 SEC63 homolog (S. cerevisiae)".
^ Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kääriäinen H, Höckerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S (June 2004). "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. doi:10.1038/ng1357. PMID 15133510.

Meyer HA, Grau H, Kraft R, et al. (2000). "Mammalian Sec61 is associated with Sec62 and Sec63". J. Biol. Chem. 275 (19): 14550–7. doi:10.1074/jbc.275.19.14550. PMID 10799540.
Ponting CP (2001). "Proteins of the endoplasmic-reticulum-associated degradation pathway: domain detection and function prediction". Biochem. J. 351. Pt 2: 527–35. PMC 1221390. PMID 11023840.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Davila S, Furu L, Gharavi AG, et al. (2004). "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. doi:10.1038/ng1357. PMID 15133510.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
You KT, Li LS, Kim NG, et al. (2007). "Selective translational repression of truncated proteins from frameshift mutation-derived mRNAs in tumors". PLOS Biol. 5 (5): e109. doi:10.1371/journal.pbio.0050109. PMC 1854916. PMID 17456004.{{cite journal}}: CS1 maint: unflagged free DOI (link)

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000025796 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000019802 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10219736-5] Woollatt E, Pine KA, Shine J, Sutherland GR, Iismaa TP (Jun 1999). "Human Sec63 endoplasmic reticulum membrane protein, map position 6q21". Chromosome Res. 7 (1): 77. doi:10.1023/A:1009283530544. PMID 10219736. S2CID 19417266.

[pmid10543453-6] Skowronek MH, Rotter M, Haas IG (Nov 1999). "Molecular characterization of a novel mammalian DnaJ-like Sec63p homolog". Biol Chem. 380 (9): 1133–8. doi:10.1515/BC.1999.142. PMID 10543453. S2CID 46726981.

[entrez-7] "Entrez Gene: SEC63 SEC63 homolog (S. cerevisiae)".

[pmid15133510-8] Davila S, Furu L, Gharavi AG, Tian X, Onoe T, Qian Q, Li A, Cai Y, Kamath PS, King BF, Azurmendi PJ, Tahvanainen P, Kääriäinen H, Höckerstedt K, Devuyst O, Pirson Y, Martin RS, Lifton RP, Tahvanainen E, Torres VE, Somlo S (June 2004). "Mutations in SEC63 cause autosomal dominant polycystic liver disease". Nat. Genet. 36 (6): 575–7. doi:10.1038/ng1357. PMID 15133510.

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Function

Clinical significance

References

Further reading