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Protein-coding gene in the species Homo sapiens
Zinc finger FYVE domain-containing protein 1 is a protein that in humans is encoded by the ZFYVE1 gene .[ 5] [ 6] [ 7]
The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc -binding FYVE domains in tandem. This protein displays a predominantly Golgi , endoplasmic reticulum and vesicular distribution.
Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000165861 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042628 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Derubeis AR, Young MF, Jia L, Robey PG, Fisher LW (Nov 2000). "Double FYVE-containing protein 1 (DFCP1): isolation, cloning and characterization of a novel FYVE finger protein from a human bone marrow cDNA library" . Gene . 255 (2): 195–203. doi :10.1016/S0378-1119(00)00303-6 . PMID 11024279 . ^ Cheung PC, Trinkle-Mulcahy L, Cohen P, Lucocq JM (Mar 2001). "Characterization of a novel phosphatidylinositol 3-phosphate-binding protein containing two FYVE fingers in tandem that is targeted to the Golgi" . Biochem J . 355 (Pt 1): 113–21. doi :10.1042/0264-6021:3550113 . PMC 1221718 PMID 11256955 . ^ a b "Entrez Gene: ZFYVE1 zinc finger, FYVE domain containing 1" .
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