HTATSF1

HTATSF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DIT
Identifiers
Aliases	HTATSF1, TAT-SF1, TATSF1, dJ196E23.2, HIV-1 Tat specific factor 1
External IDs	OMIM: 300346; MGI: 1919709; HomoloGene: 40950; GeneCards: HTATSF1; OMA:HTATSF1 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	136,512,346 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	56,112,543 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Skeletal muscle tissue of rectus abdominis; ; pituitary gland; ; germinal epithelium; ; internal globus pallidus; ; epithelium of nasopharynx; ; ganglionic eminence; ; tendon of biceps brachii; ; vastus lateralis muscle; ; anterior pituitary;
	Top expressed in
	pituitary gland; ; saccule; ; vas deferens; ; fossa; ; condyle; ; otic vesicle; ; ankle; ; otic placode; ; triceps brachii muscle; ; temporal muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleic acid binding; RNA binding;
Cellular component	U2-type spliceosomal complex; nucleus; U2 snRNP; nucleoplasm;
Biological process	regulation of transcription by RNA polymerase II; viral genome replication; regulation of DNA-templated transcription, elongation; regulation of transcription, DNA-templated; transcription, DNA-templated; mRNA splicing, via spliceosome;
	Sources:Amigo / QuickGO
Orthologs
	27336
	72459
	ENSG00000102241
	ENSMUSG00000067873
	O43719
	Q8BGC0
	NM_001163280; NM_014500
	NM_028242; NM_029371
	NP_001156752; NP_055315
	NP_082518; NP_083647
	Wikidata
View/Edit Human	View/Edit Mouse

HIV Tat-specific factor 1 is a protein that in humans is encoded by the HTATSF1 gene.^[5]^[6]

Function

Whereas most DNA sequence-specific transcription factors increase the rate of initiation and interact with enhancer or promoter DNA, human immunodeficiency virus-1 (HIV-1) Tat predominantly stimulates elongation and interacts with the trans-acting responsive (TAR) RNA element. Tat is essential for HIV replication.^[6]

HTATSF1 has also been shown to be involved in intron retention, and is associated with splicing of mRNAs that encode ribosomal proteins.^[7] It is also associated with a naïve pluripotent state, although the relationship is complex and is strongly affected by other pluripotency factors such as Nanog and KLF2.^[7]

Interactions

HTATSF1 has been shown to interact with SUPT5H^[8] and GTF2F2.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102241 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000067873 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou Q, Sharp PA (November 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
^ ^a ^b "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1".
^ ^a ^b Corsini, Nina S.; Peer, Angela M.; Moeseneder, Paul; Roiuk, Mykola; Burkard, Thomas R.; Theussl, Hans-Christian; Moll, Isabella; Knoblich, Juergen A. (April 2018). "Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation". Cell Stem Cell. 22 (4): 543–558.e12. doi:10.1016/j.stem.2018.03.002. ISSN 1934-5909. PMID 29625069.
^ ^a ^b Kim, J B; Yamaguchi Y; Wada T; Handa H; Sharp P A (September 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN 0270-7306. PMC 84462. PMID 10454543.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Zhou Q, Chen D, Pierstorff E, Luo K (1998). "Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages". EMBO J. 17 (13): 3681–91. doi:10.1093/emboj/17.13.3681. PMC 1170704. PMID 9649438.
Yan D, Perriman R, Igel H, et al. (1998). "CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif". Mol. Cell. Biol. 18 (9): 5000–9. doi:10.1128/MCB.18.9.5000. PMC 109085. PMID 9710584.
Li XY, Green MR (1998). "The HIV-1 Tat cellular coactivator Tat-SF1 is a general transcription elongation factor". Genes Dev. 12 (19): 2992–6. doi:10.1101/gad.12.19.2992. PMC 317190. PMID 9765201.
Parada CA, Roeder RG (1999). "A novel RNA polymerase II-containing complex potentiates Tat-enhanced HIV-1 transcription". EMBO J. 18 (13): 3688–701. doi:10.1093/emboj/18.13.3688. PMC 1171446. PMID 10393184.
Kim JB, Yamaguchi Y, Wada T, et al. (1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. PMC 84462. PMID 10454543.
Fong YW, Zhou Q (2000). "Relief of two built-In autoinhibitory mechanisms in P-TEFb is required for assembly of a multicomponent transcription elongation complex at the human immunodeficiency virus type 1 promoter". Mol. Cell. Biol. 20 (16): 5897–907. doi:10.1128/MCB.20.16.5897-5907.2000. PMC 86067. PMID 10913173.
Suñé C, Goldstrohm AC, Peng J, et al. (2000). "An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation". Virology. 274 (2): 356–66. doi:10.1006/viro.2000.0480. PMID 10964778.
Simmons A, Aluvihare V, McMichael A (2001). "Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators". Immunity. 14 (6): 763–77. doi:10.1016/S1074-7613(01)00158-3. PMID 11420046.
Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature. 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068. S2CID 1518837.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Zhou BY, He JJ (2004). "Proliferation inhibition of astrocytes, neurons, and non-glial cells by intracellularly expressed human immunodeficiency virus type 1 (HIV-1) Tat protein". Neurosci. Lett. 359 (3): 155–8. doi:10.1016/j.neulet.2004.02.012. PMID 15050687. S2CID 3048557.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Smith MJ, Kulkarni S, Pawson T (2004). "FF domains of CA150 bind transcription and splicing factors through multiple weak interactions". Mol. Cell. Biol. 24 (21): 9274–85. doi:10.1128/MCB.24.21.9274-9285.2004. PMC 522232. PMID 15485897.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhou M, Deng L, Lacoste V, et al. (2004). "Coordination of transcription factor phosphorylation and histone methylation by the P-TEFb kinase during human immunodeficiency virus type 1 transcription". J. Virol. 78 (24): 13522–33. doi:10.1128/JVI.78.24.13522-13533.2004. PMC 533906. PMID 15564463.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286. PMID 15772651.
Missé D, Gajardo J, Oblet C, et al. (2005). "Soluble HIV-1 gp120 enhances HIV-1 replication in non-dividing CD4+ T cells, mediated via cell signaling and Tat cofactor overexpression". AIDS. 19 (9): 897–905. doi:10.1097/01.aids.0000171403.07995.92. PMID 15905670. S2CID 23688259.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102241 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000067873 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8849451-5] Zhou Q, Sharp PA (November 1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.

[entrez-6] "Entrez Gene: HTATSF1 HIV-1 Tat specific factor 1".

[:0-7] Corsini, Nina S.; Peer, Angela M.; Moeseneder, Paul; Roiuk, Mykola; Burkard, Thomas R.; Theussl, Hans-Christian; Moll, Isabella; Knoblich, Juergen A. (April 2018). "Coordinated Control of mRNA and rRNA Processing Controls Embryonic Stem Cell Pluripotency and Differentiation". Cell Stem Cell. 22 (4): 543–558.e12. doi:10.1016/j.stem.2018.03.002. ISSN 1934-5909. PMID 29625069.

[pmid10454543-8] Kim, J B; Yamaguchi Y; Wada T; Handa H; Sharp P A (September 1999). "Tat-SF1 protein associates with RAP30 and human SPT5 proteins". Mol. Cell. Biol. 19 (9): 5960–8. doi:10.1128/mcb.19.9.5960. ISSN 0270-7306. PMC 84462. PMID 10454543.

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Function

Interactions

References

Further reading