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Protein-coding gene in the species Homo sapiens
Rhombotin-1 is a protein that in humans is encoded by the LMO1 gene .[ 5] [ 6] [ 7]
LMO1 encodes a cysteine-rich, two LIM domain transcriptional regulator. It is mapped to an area of consistent chromosomal translocation in chromosome 11, disrupting it in T-cell leukemia, although more rarely than the related gene, LMO2 is disrupted.[ 7]
Interactions
LMO1 has been shown to interact with GATA3 [ 8] [ 9] TAL1 .[ 10] [ 11]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000166407 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036111 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Boehm T, Foroni L, Kaneko Y, Perutz MF, Rabbitts TH (June 1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13" . Proc Natl Acad Sci U S A . 88 (10): 4367–71. Bibcode :1991PNAS...88.4367B . doi :10.1073/pnas.88.10.4367 PMC 51660 PMID 2034676 . ^ McGuire EA, Davis AR, Korsmeyer SJ (March 1991). "T-cell translocation gene 1 (Ttg-1) encodes a nuclear protein normally expressed in neural lineage cells" . Blood . 77 (3): 599–606. doi :10.1182/blood.V77.3.599.599 PMID 1703797 . ^ a b "Entrez Gene: LMO1 LIM domain only 1 (rhombotin 1)" .^ Ono, Y; Fukuhara N; Yoshie O (December 1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3" . Mol. Cell. Biol . 18 (12): 6939–50. doi :10.1128/MCB.18.12.6939 . ISSN 0270-7306 . PMC 109277 PMID 9819382 . ^ Ono, Y; Fukuhara N; Yoshie O (February 1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL" . J. Biol. Chem . 272 (7): 4576–81. doi :10.1074/jbc.272.7.4576 ISSN 0021-9258 . PMID 9020185 . ^ Valge-Archer, V E; Osada H; Warren A J; Forster A; Li J; Baer R; Rabbitts T H (August 1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells" . Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. Bibcode :1994PNAS...91.8617V . doi :10.1073/pnas.91.18.8617 ISSN 0027-8424 . PMC 44657 PMID 8078932 . ^ Wadman, I; Li J; Bash R O; Forster A; Osada H; Rabbitts T H; Baer R (October 1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . EMBO J . 13 (20): 4831–9. doi :10.1002/j.1460-2075.1994.tb06809.x . ISSN 0261-4189 . PMC 395422 PMID 7957052 .
Further reading
Foroni L, Boehm T, White L, et al. (1992). "The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development". J. Mol. Biol . 226 (3): 747–61. doi :10.1016/0022-2836(92)90630-3 . PMID 1507224 . Boehm T, Spillantini MG, Sofroniew MV, et al. (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression". Oncogene . 6 (5): 695–703. PMID 2052354 . Chen Q, Cheng JT, Tasi LH, et al. (1990). "The tal gene undergoes chromosome translocation in T cell leukemia and potentially encodes a helix-loop-helix protein" . EMBO J . 9 (2): 415–24. doi :10.1002/j.1460-2075.1990.tb08126.x . PMC 551682 PMID 2303035 . Boehm T, Greenberg JM, Buluwela L, et al. (1990). "An unusual structure of a putative T cell oncogene which allows production of similar proteins from distinct mRNAs" . EMBO J . 9 (3): 857–68. doi :10.1002/j.1460-2075.1990.tb08183.x . PMC 551746 PMID 2311586 . McGuire EA, Hockett RD, Pollock KM, et al. (1989). "The t(11;14)(p15;q11) in a T-cell acute lymphoblastic leukemia cell line activates multiple transcripts, including Ttg-1, a gene encoding a potential zinc finger protein" . Mol. Cell. Biol . 9 (5): 2124–32. doi :10.1128/MCB.9.5.2124 . PMC 363006 PMID 2501659 . Boehm T, Baer R, Lavenir I, et al. (1988). "The mechanism of chromosomal translocation t(11;14) involving the T-cell receptor C delta locus on human chromosome 14q11 and a transcribed region of chromosome 11p15" . EMBO J . 7 (2): 385–94. doi :10.1002/j.1460-2075.1988.tb02825.x . PMC 454331 PMID 3259177 . Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia" . EMBO J . 13 (20): 4831–9. doi :10.1002/j.1460-2075.1994.tb06809.x . PMC 395422 PMID 7957052 . Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells" . Proc. Natl. Acad. Sci. U.S.A . 91 (18): 8617–21. Bibcode :1994PNAS...91.8617V . doi :10.1073/pnas.91.18.8617 PMC 44657 PMID 8078932 . Arber S, Caroni P (1996). "Specificity of single LIM motifs in targeting and LIM/LIM interactions in situ" . Genes Dev . 10 (3): 289–300. doi :10.1101/gad.10.3.289 PMID 8595880 . Jurata LW, Kenny DA, Gill GN (1996). "Nuclear LIM interactor, a rhombotin and LIM homeodomain interacting protein, is expressed early in neuronal development" . Proc. Natl. Acad. Sci. U.S.A . 93 (21): 11693–8. Bibcode :1996PNAS...9311693J . doi :10.1073/pnas.93.21.11693 PMC 38120 PMID 8876198 . Ono Y, Fukuhara N, Yoshie O (1997). "Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL" . J. Biol. Chem . 272 (7): 4576–81. doi :10.1074/jbc.272.7.4576 PMID 9020185 . Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11)". Oncogene . 17 (24): 3199–202. doi :10.1038/sj.onc.1202353 . PMID 9872335 . Bao J, Talmage DA, Role LW, Gautier J (2000). "Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins". Development . 127 (2): 425–35. doi :10.1242/dev.127.2.425 . PMID 10603358 . Cichutek A, Brueckmann T, Seipel B, et al. (2001). "Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)". Cytogenet. Cell Genet . 93 (3–4): 277–83. doi :10.1159/000056998 . PMID 11528126 . S2CID 25807985 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Lin YW, Deveney R, Barbara M, et al. (2005). "OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1" . Cancer Res . 65 (16): 7151–8. doi :10.1158/0008-5472.CAN-05-1400 . PMC 1681523 PMID 16103065 . Saeki N, Kim DH, Usui T, et al. (2007). "GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling". Oncogene . 26 (45): 6488–98. doi :10.1038/sj.onc.1210475 . PMID 17471240 .
