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Ruth Lehmann

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Ruth Lehmann
Born
Germany
Alma materUniversity of Tübingen
Awards
Scientific career
FieldsDevelopmental and cell biology
InstitutionsNew York University School of Medicine
Doctoral advisorChristiane Nüsslein-Volhard
Websitelehmannlab.med.nyu.edu

Ruth Lehmann is a developmental and cell biologist. She is the Director of the Whitehead Institute for Biomedical Research.[1] She previously was affiliated with the New York University School of Medicine, where she was the Director of the Skirball Institute of Biomolecular Medicine, the Laura and Isaac Perlmutter Professor of Cell Biology, and the Chair of the Department of Cell Biology. Her research focuses on germ cells and embryogenesis.

Early life

Lehmann initially became interested in science during her early years at home.[2] Her mother served as a teacher and loved both the arts and literature, while her father worked as an engineer. She developed a particular interest in biology, which was in part fueled by a high school biology teacher who encouraged her to pursue the subject at a university.

Education

Lehmann attended the University of Tübingen in Germany to pursue a major in biology.[3] Despite her love for the subject, she was unhappy with the teaching environment and found the courses tedious.[2] Following strong encouragement from American faculty, she applied for and was granted a Fulbright Fellowship in 1977 to study ecology in the United States.[4] After realizing that she preferred genetics and mathematics to ecology, she connected with Gerold Schubiger, a geneticist studying fruit fly development in Seattle, Washington where she learned classical developmental biology.[5] Following her year-long fellowship, Lehmann attended her first scientific conference, the 1978 Society for Developmental Biology meeting in Madison, Wisconsin.[2] There she met her future mentor and friend Christiane Nüsslein-Volhard. As Nüsslein-Volhard was moving to an independent position at the European Molecular Biology Laboratory in Heidelberg, which was not associated with a graduate program, she referred Lehmann to José Campos-Ortega, a researcher at Freiburg University studying the neurobiology of Drosophila [5]. Lehmann worked closely with both Campos-Ortega and Nüsslein-Volhard and returned to Tübingen the following year to earn her Ph.D. with Nüsslein-Volhard, at the Max Planck Institute for Developmental Biology, studying the maternal genes affecting embryonic development in fruit flies.[4] Lehmann then accepted a post-doctoral position at the MRC Laboratory of Molecular Biology in Cambridge, England.

Academic career

Following her post-doctoral position at the MRC Laboratory of Molecular Biology, Lehmann returned to the United States to found her own laboratory at the Massachusetts Institute of Technology.[4] She remained at MIT for 8 years, serving as a faculty member at both MIT and the Whitehead Institute for Biomedical Research, in addition to working as a geneticist and molecular biologist at the Massachusetts General Hospital.[3] In 1994, Lehmann was one of 16 women faculty in the School of Science at MIT who drafted and co-signed a letter to the then-Dean of Science (now Chancellor of Berkeley) Robert Birgeneau, which started a campaign to highlight and challenge gender discrimination at MIT.[6]

Lehmann then moved to the Skirball Institute of Biomolecular Medicine at New York University in 1996 as the Laura and Isaac Perlmutter Professor of Cell Biology. She has since become the director of the Skirball Institute and the Helen L. and Martin S. Kimmel Center for Stem Cell Biology, and has recently been named chair of the Cell Biology Department.[7]

Lehmann has served as president of the Society of Developmental Biology, president of the Harvey Society, and council member of the American Society for Cell Biology. In addition, she has founded and advised graduate programs for NYU Medical Center, Harvard Medical School, University of California San Francisco, and more. She is on the council for the National Institute of Child Health and serves as editor for a number of scientific journals including Cell, Developmental Biology and the Annual Review of Cell and Developmental Biology.[8]

As of September 2019, Dr. Lehmann was announced as the new Director of the Whitehead Institute for Biomedical Research, succeeding David Page.

Awards, honors, and tributes

Lehman has been a member of the National Academy of Sciences since 2005, one of the most prestigious honorary organizations for scientists in the nation.[3] She was also named a Howard Hughes Medical Institute Investigator and was elected to the American Academy of Arts and Sciences, as well as the European Molecular Biology Organization. In 2011 she was awarded the Conklin Medal of the Society of Developmental Biology. She is the recipient of the 2021 Vilcek Prize in Biomedical Science,[9] awarded by the Vilcek Foundation.[10] In 2021 she received an honorary doctorate from the University of Basel.[11] In 2022 she was awarded the Gruber Prize in Genetics.[12]

Research

Lehmann published her first paper in 1981 under her Fulbright Fellowship mentor Campos-Ortega, detailing her study of early neurogenesis in Drosophila and the effects of lethal mutations on neural and epidermal cell precursors.[13] Under Nüsslein-Volhard, Lehmann began to study maternal genes like oskar, pumilio, and nanos, comparing the effects of maternal versus zygotic genes in germ cell formation, abdominal patterning, and cell signaling.[14][15] Using molecular cloning techniques, she discovered that oskar and nanos RNA transcripts regulate gene expression and germ cell formation by localizing at the posterior embryonic pole.[16][17] Her later work continues to build on this discovery by analyzing modification mechanisms of RNA transcript production and how they affect germ cell differentiation and localization in Drosophila. Among other mechanisms, her laboratory discovered that a polyadenylated tail is not required for gene regulation.[16]

Lehmann continued to focus her research efforts on germ cell differentiation well into the early 2000s. She played a substantial role in the discovery of germ cell migratory pathways (namely those involving gap junctions, G protein-coupled receptors like Tre-1, and isoprenoids), particularly those concerning migration into the ovaries and testis.[18][19][20] In 2005, Lehmann's laboratory published a paper relating the lipid phosphatases Wunen and Wunen 2 to germ cell migration and elimination, suggesting that germ cells are sorted into the gonads by a type of repellent mechanism.[21] Her findings up to this point indicated that germ cells avoid differentiation into somatic cells through a combination of her previously studied regulatory mechanisms, each of which has the potential to silence transcription and control translation.

Currently, Lehmann is studying piRNA production and the role it plays in preventing transposable element insertion and movement across the Drosophila genome.[22] She discovered that biogenesis of piRNAs and activation of the piRNA pathway is directly dependent on a number of proteins and epigenetic interactions. These results indicate that piRNAs play a paramount role in maintaining genomic integrity while allowing for genetic variation to occur.

References

  1. ^ "Lehmann Lab". Lehmann Lab. Retrieved 10 April 2016.
  2. ^ a b c Sedwick, Caitlin (2011-09-05). "Ruth Lehmann: Germ cells do things differently". The Journal of Cell Biology. 194 (5): 660–661. doi:10.1083/jcb.1945pi. ISSN 0021-9525. PMC 3171127. PMID 21893593.
  3. ^ a b c "Ruth Lehmann named as Department Chair | Department of Cell Biology". med.nyu.edu. Retrieved 2017-11-25.
  4. ^ a b c "Ruth Lehmann, PhD | HHMI.org". HHMI.org. Retrieved 2017-11-25.
  5. ^ a b "Ruth Lehmann". www.sdbonline.org. Retrieved 2020-05-02.
  6. ^ Zernike, Kate (2023). The Exceptions: Nancy Hopkins, MIT, and the Fight for Women in Science. New York, NY: Scribner. ISBN 978-1-9821-3183-8.
  7. ^ "Ruth Lehmann". www.sdbonline.org. Retrieved 2017-11-25.
  8. ^ Lehmann, Ruth (2018). "Introduction: Challenges for Science: A Retrospective". Annual Review of Cell and Developmental Biology. 34: v–viii. doi:10.1146/annurev-cb-34-030918-100001. PMID 30296393.
  9. ^ "Ruth Lehmann". Vilcek Foundation. Retrieved 2020-09-09.
  10. ^ "2021 Vilcek Foundation Prizes in Biomedical Science Recognize Immigrant Leaders in STEM". Vilcek Foundation. Retrieved 2020-09-09.
  11. ^ "Dies Academicus 2021: University of Basel presents seven female honorary doctors". www.unibas.ch. Retrieved 2021-12-22.
  12. ^ Gruber Prize in Genetics 2022
  13. ^ Lehmann, Ruth; Dietrich, Ursula; Jiménez, F.; Campos-Ortega, J. A. (1981-07-01). "Mutations of early neurogenesis in Drosophila". Wilhelm Roux's Archives of Developmental Biology. 190 (4): 226–229. doi:10.1007/bf00848307. ISSN 0340-0794. PMID 28305572. S2CID 21814447.
  14. ^ Lehmann, Ruth; Nüsslein-Volhard, Christiane (1987-09-10). "Involvement of the pumilio gene in the transport of an abdominal signal in the Drosophila embryo". Nature. 329 (6135): 167–170. Bibcode:1987Natur.329..167L. doi:10.1038/329167a0. ISSN 1476-4687. S2CID 4355300.
  15. ^ Lehmann, Ruth (1988-10-01). "Phenotypic comparison between maternal and zygotic genes controlling the segmental pattern of the Drosophila embryo". Development. 104 (Supplement): 17–27. doi:10.1242/dev.104.Supplement.17. ISSN 0950-1991.
  16. ^ a b Chagnovich, D.; Lehmann, R. (2001-09-25). "Poly(A)-independent regulation of maternal hunchback translation in the Drosophila embryo". Proceedings of the National Academy of Sciences of the United States of America. 98 (20): 11359–11364. Bibcode:2001PNAS...9811359C. doi:10.1073/pnas.201284398. ISSN 0027-8424. PMC 58734. PMID 11562474.
  17. ^ Gavis, Elizabeth R.; Lehmann, Ruth (1994-05-26). "Translational regulation of nanos by RNA localization". Nature. 369 (6478): 315–318. Bibcode:1994Natur.369..315G. doi:10.1038/369315a0. ISSN 1476-4687. PMID 7514276. S2CID 4369219.
  18. ^ Kunwar, Prabhat S.; Starz-Gaiano, Michelle; Bainton, Roland J.; Heberlein, Ulrike; Lehmann, Ruth (2003-12-22). "Tre1, a G Protein-Coupled Receptor, Directs Transepithelial Migration of Drosophila Germ Cells". PLOS Biology. 1 (3): e80. doi:10.1371/journal.pbio.0000080. ISSN 1545-7885. PMC 300690. PMID 14691551.
  19. ^ Gilboa, Lilach; Forbes, Alexandria; Tazuke, Salli I.; Fuller, Margaret T.; Lehmann, Ruth (2003-12-29). "Germ line stem cell differentiation in Drosophila requires gap junctions and proceeds via an intermediate state". Development. 130 (26): 6625–6634. doi:10.1242/dev.00853. ISSN 0950-1991. PMID 14660550.
  20. ^ Santos, Ana C; Lehmann, Ruth (2004). "Isoprenoids Control Germ Cell Migration Downstream of HMGCoA Reductase". Developmental Cell. 6 (2): 283–293. doi:10.1016/s1534-5807(04)00023-1. PMID 14960281.
  21. ^ Sano, Hiroko; Renault, Andrew D.; Lehmann, Ruth (2005-11-21). "Control of lateral migration and germ cell elimination by the Drosophila melanogaster lipid phosphate phosphatases Wunen and Wunen 2". The Journal of Cell Biology. 171 (4): 675–683. doi:10.1083/jcb.200506038. ISSN 0021-9525. PMC 2171572. PMID 16301333.
  22. ^ Rangan, Prashanth; Malone, Colin D.; Navarro, Caryn; Newbold, Sam P.; Hayes, Patrick S.; Sachidanandam, Ravi; Hannon, Gregory J.; Lehmann, Ruth (2011-08-23). "piRNA production requires heterochromatin formation in Drosophila". Current Biology. 21 (16): 1373–1379. doi:10.1016/j.cub.2011.06.057. ISSN 1879-0445. PMC 3205116. PMID 21820311.
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