WD repeat domain 18

WDR18
Identifiers
Aliases	WDR18, Ipi3, R32184_1, WD repeat domain 18
External IDs	MGI: 2158400; HomoloGene: 32573; GeneCards: WDR18; OMA:WDR18 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	998,438 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	79,806,037 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right lobe of liver; ; mucosa of transverse colon; ; apex of heart; ; anterior pituitary; ; right adrenal cortex; ; right frontal lobe; ; left adrenal gland; ; muscle of thigh; ; left adrenal cortex;
	Top expressed in
	epiblast; ; embryo; ; embryo; ; morula; ; right kidney; ; blastocyst; ; hand; ; spermatid; ; spermatocyte; ; neural tube;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	nucleus; cytoplasm; nucleoplasm; nucleolus; nuclear pre-replicative complex; Rix1 complex;
Biological process	multicellular organism development; rRNA processing; ribosomal large subunit assembly; pre-replicative complex assembly involved in nuclear cell cycle DNA replication; regulation of DNA-dependent DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	57418
	216156
	ENSG00000065268
	ENSMUSG00000035754
	Q9BV38
	Q4VBE8
	NM_024100; NM_001372085; NM_001372086
	NM_175450
	NP_077005; NP_001359014; NP_001359015
	NP_780659
	Wikidata
View/Edit Human	View/Edit Mouse

WD repeat domain 18 is a protein that in humans is encoded by the WDR18 gene. ^[5]

Function

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065268 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035754 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: WD repeat domain 18". Retrieved 2017-08-12.

Function

References

Further reading