ADAP2

ADAP2
Identifiers
Aliases	ADAP2, CENTA2, HSA272195, cent-b, ArfGAP with dual PH domains 2
External IDs	OMIM: 608635; MGI: 2663075; HomoloGene: 10179; GeneCards: ADAP2; OMA:ADAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	30,959,322 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,178,958 bp
RNA expression pattern
	Top expressed in
	monocyte; ; synovial membrane; ; amniotic fluid; ; granulocyte; ; placenta; ; spleen; ; trabecular bone; ; gingival epithelium; ; blood; ; synovial joint;
	Top expressed in
	Rostral migratory stream; ; right kidney; ; stroma of bone marrow; ; lumbar subsegment of spinal cord; ; left lobe of liver; ; human kidney; ; jejunum; ; blastocyst; ; duodenum; ; proximal tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol 1,3,4,5 tetrakisphosphate binding; protein-macromolecule adaptor activity; phosphatidylinositol-4,5-bisphosphate binding; protein binding; phosphatidylinositol-3,4,5-trisphosphate binding; metal ion binding; GTPase activator activity; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol bisphosphate binding;
Cellular component	cytoplasm; plasma membrane; mitochondrial envelope; membrane;
Biological process	heart development; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	55803
	216991
	ENSG00000184060
	ENSMUSG00000020709
	Q9NPF8
	Q8R2V5
	NM_001346712; NM_001346714; NM_001346716; NM_018404
	NM_172133
	NP_001333641; NP_001333643; NP_001333645; NP_060874
	NP_742145
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with dual PH domain-containing protein 2 is a protein that in humans is encoded by the ADAP2 gene.^[5]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184060 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020709 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: CENTA2 centaurin, alpha 2".

External links

Human ADAP2 genome location and ADAP2 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y; Yoshitomo-Nakagawa K; Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Jenne DE; Tinschert S; Stegmann E; et al. (2000). "A common set of at least 11 functional genes is lost in the majority of NF1 patients with gross deletions". Genomics. 66 (1): 93–7. doi:10.1006/geno.2000.6179. PMID 10843809. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Whitley P; Gibbard AM; Koumanov F; et al. (2003). "Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle". Eur. J. Cell Biol. 81 (4): 222–30. doi:10.1078/0171-9335-00242. PMID 12018390. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Hanck T, Stricker R, Sedehizade F, Reiser G (2004). "Identification of gene structure and subcellular localization of human centaurin alpha 2, and p42IP4, a family of two highly homologous, Ins 1,3,4,5-P4-/PtdIns 3,4,5-P3-binding, adapter proteins". J. Neurochem. 88 (2): 326–36. doi:10.1046/j.1471-4159.2003.02143.x. PMID 14690521.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Venturin M; Bentivegna A; Moroni R; et al. (2005). "Evidence by expression analysis of candidate genes for congenital heart defects in the NF1 microdeletion interval". Ann. Hum. Genet. 69 (Pt 5): 508–16. doi:10.1111/j.1529-8817.2005.00203.x. PMID 16138909. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Douglas J; Cilliers D; Coleman K; et al. (2007). "Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth". Nat. Genet. 39 (8): 963–5. doi:10.1038/ng2083. PMID 17632510. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184060 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020709 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CENTA2 centaurin, alpha 2".

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References

External links

Further reading