TAF1A

TAF1A
Identifiers
Aliases	TAF1A, MGC:17061, RAFI48, SL1, TAFI48, TATA-box binding protein associated factor, RNA polymerase I subunit A
External IDs	OMIM: 604903; MGI: 109578; HomoloGene: 4155; GeneCards: TAF1A; OMA:TAF1A - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	222,589,933 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	183,191,020 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; testicle; ; ventricular zone; ; gonad; ; ganglionic eminence; ; Achilles tendon; ; monocyte; ; lymph node; ; stromal cell of endometrium;
	Top expressed in
	primary oocyte; ; zygote; ; secondary oocyte; ; neural layer of retina; ; Ileal epithelium; ; spermatocyte; ; ventricular zone; ; Paneth cell; ; medullary collecting duct; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding;
Cellular component	microtubule cytoskeleton; RNA polymerase I transcription regulator complex; nucleus; nucleoplasm;
Biological process	transcription initiation from RNA polymerase I promoter; transcription by RNA polymerase I; termination of RNA polymerase I transcription; epigenetic maintenance of chromatin in transcription-competent conformation; transcription by RNA polymerase II; regulation of transcription, DNA-templated; transcription, DNA-templated; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	9015
	21339
	ENSG00000143498
	ENSMUSG00000072258
	Q15573; Q5JRA7
	P97357
	NM_001201536; NM_005681; NM_139352
	NM_001277957; NM_001277958; NM_001277959; NM_021466
	NP_001188465; NP_005672; NP_647603
	NP_001264886; NP_001264887; NP_001264888; NP_067441
	Wikidata
View/Edit Human	View/Edit Mouse

TATA box-binding protein-associated factor RNA polymerase I subunit A is an enzyme that in humans is encoded by the TAF1A gene.^[5]^[6]

Function

Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as selective factor 1 (SL1), binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes the smallest SL1-specific TAF. Two transcripts encoding different isoforms have been identified.^[6]

Interactions

TAF1A has been shown to interact with Acidic leucine-rich nuclear phosphoprotein 32 family member A^[7] and Protein SET.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143498 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000072258 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.
^ ^a ^b "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".
^ ^a ^b Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.

Rudloff U, Eberhard D, Tora L, Stunnenberg H, Grummt I (1994). "TBP-associated factors interact with DNA and govern species specificity of RNA polymerase I transcription". EMBO J. 13 (11): 2611–6. PMC 395135. PMID 8013460.
Di Pietro C, Rapisarda A, Amico V, Bonaiuto C, Viola A, Scalia M, Motta S, Amato A, Engel H, Messina A, Sichel G, Grzeschik K, Purrello M (2000). "Genomic localization of the human genes TAF1A, TAF1B and TAF1C, encoding TAF(I)48, TAF(I)63 and TAF(I)110 subunits of class I general transcription initiation factor SL1". Cytogenet. Cell Genet. 89 (1–2): 133–6. doi:10.1159/000015592. PMID 10894955.
Zhai W, Comai L (2000). "Repression of RNA polymerase I transcription by the tumor suppressor p53". Mol. Cell. Biol. 20 (16): 5930–8. doi:10.1128/MCB.20.16.5930-5938.2000. PMC 86070. PMID 10913176.
Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.
Miller G, Panov KI, Friedrich JK, Trinkle-Mulcahy L, Lamond AI, Zomerdijk JC (2001). "hRRN3 is essential in the SL1-mediated recruitment of RNA Polymerase I to rRNA gene promoters". EMBO J. 20 (6): 1373–82. doi:10.1093/emboj/20.6.1373. PMC 145519. PMID 11250903.
Dynes JL, Xu S, Bothner S, Lahti JM, Hori RT (2004). "The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors". J. Biochem. 135 (3): 429–38. doi:10.1093/jb/mvh051. PMID 15113842.
Yamamoto K, Yamamoto M, Hanada K, Nogi Y, Matsuyama T, Muramatsu M (2004). "Multiple protein-protein interactions by RNA polymerase I-associated factor PAF49 and role of PAF49 in rRNA transcription". Mol. Cell. Biol. 24 (14): 6338–49. doi:10.1128/MCB.24.14.6338-6349.2004. PMC 434256. PMID 15226435.
Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ (2005). "c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I". Nat. Cell Biol. 7 (3): 311–8. doi:10.1038/ncb1224. PMID 15723054.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000143498 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000072258 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7801123-5] Comai L, Zomerdijk JC, Beckmann H, Zhou S, Admon A, Tjian R (December 1994). "Reconstitution of transcription factor SL1: exclusive binding of TBP by SL1 or TFIID subunits". Science. 266 (5193): 1966–72. doi:10.1126/science.7801123. PMID 7801123.

[entrez-6] "Entrez Gene: TAF1A TATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDa".

[pmid11163245-7] Seo SB, McNamara P, Heo S, Turner A, Lane WS, Chakravarti D (January 2001). "Regulation of histone acetylation and transcription by INHAT, a human cellular complex containing the set oncoprotein". Cell. 104 (1): 119–30. doi:10.1016/S0092-8674(01)00196-9. PMID 11163245.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

Function

Interactions

References

Further reading