PCDH10

PCDH10
Identifiers
Aliases	PCDH10, OL-PCDH, PCDH19, protocadherin 10
External IDs	OMIM: 608286; MGI: 1338042; HomoloGene: 74967; GeneCards: PCDH10; OMA:PCDH10 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	133,208,606 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	45,390,058 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; prefrontal cortex; ; internal globus pallidus; ; Brodmann area 46; ; caudate nucleus; ; nucleus accumbens; ; superior frontal gyrus; ; Brodmann area 23; ; stromal cell of endometrium; ; putamen;
	Top expressed in
	substantia nigra; ; olfactory tubercle; ; lateral hypothalamus; ; globus pallidus; ; dorsomedial hypothalamic nucleus; ; primary motor cortex; ; superior frontal gyrus; ; paraventricular nucleus of hypothalamus; ; nucleus accumbens; ; medial dorsal nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	calcium ion binding;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules; cell adhesion; cell-cell signaling; nervous system development;
	Sources:Amigo / QuickGO
Orthologs
	57575
	18526
	ENSG00000138650
	ENSMUSG00000049100
	Q9P2E7
	n/a
	NM_020815; NM_032961
	NM_001098170; NM_001098171; NM_001098172; NM_011043
	NP_065866; NP_116586
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Protocadherin-10 is a protein that in humans is encoded by the PCDH10 gene.^[5]^[6]

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.
^ ^a ^b "Entrez Gene: PCDH10 protocadherin 10".

Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi:10.1101/gad.14.10.1169. PMID 10817752.
Cross SH, Charlton JA, Nan X, Bird AP (1994). "Purification of CpG islands using a methylated DNA binding column". Nat. Genet. 6 (3): 236–44. doi:10.1038/ng0394-236. PMID 8012384.
Wu Q, Maniatis T (1999). "A striking organization of a large family of human neural cadherin-like cell adhesion genes". Cell. 97 (6): 779–90. doi:10.1016/S0092-8674(00)80789-8. PMID 10380929.
Wu Q, Maniatis T (2000). "Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3124–9. doi:10.1073/pnas.060027397. PMC 16203. PMID 10716726.
Nagase T; Kikuno R; Ishikawa KI; et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wu Q; Zhang T; Cheng JF; et al. (2001). "Comparative DNA Sequence Analysis of Mouse and Human Protocadherin Gene Clusters". Genome Res. 11 (3): 389–404. doi:10.1101/gr.167301. PMC 311048. PMID 11230163. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Wolverton T, Lalande M (2001). "Identification and characterization of three members of a novel subclass of protocadherins". Genomics. 76 (1–3): 66–72. doi:10.1006/geno.2001.6592. PMID 11549318.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ying J; Li H; Seng TJ; et al. (2006). "Functional epigenetics identifies a protocadherin PCDH10 as a candidate tumor suppressor for nasopharyngeal, esophageal and multiple other carcinomas with frequent methylation". Oncogene. 25 (7): 1070–80. doi:10.1038/sj.onc.1209154. PMID 16247458. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000138650 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000049100 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10835267-5] Nollet F, Kools P, van Roy F (Jul 2000). "Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members". J Mol Biol. 299 (3): 551–72. doi:10.1006/jmbi.2000.3777. PMID 10835267.

[entrez-6] "Entrez Gene: PCDH10 protocadherin 10".

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References

Further reading