H1FX

H1-10
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LSO
Identifiers
Aliases	H1-10, H1X, H1.10, H1 histone family member X, H1FX, H1.10 linker histone
External IDs	OMIM: 602785; MGI: 2685307; HomoloGene: 4397; GeneCards: H1-10; OMA:H1-10 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	129,316,286 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	87,958,619 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; olfactory zone of nasal mucosa; ; thymus; ; ectocervix; ; right ovary; ; skin of abdomen; ; right uterine tube; ; left ovary; ; left uterine tube;
	Top expressed in
	ventricular zone; ; adrenal medulla; ; ganglionic eminence; ; white adipose tissue; ; striatum of neuraxis; ; lens; ; testicle; ; neural tube; ; primary visual cortex; ; superior frontal gyrus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; RNA binding; cadherin binding; double-stranded DNA binding; protein binding; nucleosomal DNA binding;
Cellular component	nucleosome; nucleolus; nucleus; chromosome;
Biological process	nucleosome assembly; regulation of transcription, DNA-templated; chromosome condensation; negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	8971
	243529
	ENSG00000184897
	ENSMUSG00000044927
	Q92522
	Q80ZM5
	NM_006026
	NM_198622
	NP_006017
	NP_941024
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H1x is a protein that in humans is encoded by the H1FX gene.^[5]^[6]^[7]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184897 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044927 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamamoto T, Horikoshi M (Dec 1996). "Cloning of the cDNA encoding a novel subtype of histone H1". Gene. 173 (2): 281–285. doi:10.1016/0378-1119(96)00020-0. PMID 8964515.
^ Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.
^ ^a ^b "Entrez Gene: H1FX H1 histone family, member X".

Ohsumi K, Katagiri C (1991). "Occurrence of H1 subtypes specific to pronuclei and cleavage-stage cell nuclei of anuran amphibians". Dev. Biol. 147 (1): 110–120. doi:10.1016/S0012-1606(05)80011-9. PMID 1879604.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Sulimova GE; Kutsenko AS; Rakhmanaliev ER; et al. (2003). "Human chromosome 3: integration of 60 NotI clones into a physical and gene map". Cytogenet. Genome Res. 98 (2–3): 177–183. doi:10.1159/000069814. PMID 12698000. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Beausoleil SA; Jedrychowski M; Schwartz D; et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–12135. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Garcia BA; Busby SA; Barber CM; et al. (2005). "Characterization of phosphorylation sites on histone H1 isoforms by tandem mass spectrometry". J. Proteome Res. 3 (6): 1219–1227. doi:10.1021/pr0498887. PMID 15595731. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Andersen JS; Lam YW; Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Happel N, Schulze E, Doenecke D (2005). "Characterisation of human histone H1x". Biol. Chem. 386 (6): 541–551. doi:10.1515/BC.2005.064. PMID 16006241.
Olsen JV; Blagoev B; Gnad F; et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Takata H; Matsunaga S; Morimoto A; et al. (2007). "H1.X with different properties from other linker histones is required for mitotic progression". FEBS Lett. 581 (20): 3783–3788. doi:10.1016/j.febslet.2007.06.076. PMID 17632103. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Histone H1x

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000184897 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044927 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8964515-5] Yamamoto T, Horikoshi M (Dec 1996). "Cloning of the cDNA encoding a novel subtype of histone H1". Gene. 173 (2): 281–285. doi:10.1016/0378-1119(96)00020-0. PMID 8964515.

[pmid9439656-6] Albig W, Doenecke D (Feb 1998). "The human histone gene cluster at the D6S105 locus". Hum Genet. 101 (3): 284–294. doi:10.1007/s004390050630. PMID 9439656.

[entrez-7] "Entrez Gene: H1FX H1 histone family, member X".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

References

Further reading

External links