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Phenylserine aldolase

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phenylserine aldolase
Identifiers
EC no.4.1.2.26
CAS no.37290-60-1
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a phenylserine aldolase (EC 4.1.2.26) is an enzyme that catalyzes the chemical reaction

L-threo-3-phenylserine glycine + benzaldehyde

Hence, this enzyme has one substrate, L-threo-3-phenylserine, and two products, glycine and benzaldehyde.

This enzyme belongs to the family of lyases, specifically the aldehyde-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is L-threo-3-phenylserine benzaldehyde-lyase (glycine-forming). This enzyme is also called L-threo-3-phenylserine benzaldehyde-lyase. It employs one cofactor, pyridoxal phosphate.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1V72.

References

  • BRUNS FH, FIEDLER L (1958). "Enzymatic cleavage and synthesis of L-threo-beta-phenylserine and L-erythro-beta-Phenyldrine". Nature. 181 (4622): 1533–4. doi:10.1038/1811533a0. PMID 13566053.