AFAP1

AFAP1
Identifiers
Aliases	AFAP1, AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDs	OMIM: 608252; MGI: 1917542; HomoloGene: 11009; GeneCards: AFAP1; OMA:AFAP1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	7,939,926 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	36,161,267 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; sural nerve; ; right testis; ; left testis; ; ganglionic eminence; ; muscle layer of sigmoid colon; ; epithelium of colon; ; popliteal artery; ; tibial arteries; ; testicle;
	Top expressed in
	pineal gland; ; decidua; ; iris; ; umbilical cord; ; aorta; ; superior cervical ganglion; ; otolith organ; ; calvaria; ; utricle; ; atrium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding; SH3 domain binding; SH2 domain binding;
Cellular component	cytoplasm; cytoskeleton; focal adhesion; cytosol; actin cytoskeleton;
Biological process	regulation of signal transduction; regulation of cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	60312
	70292
	ENSG00000196526
	ENSMUSG00000029094
	Q8N556
	Q80YS6
	NM_001134647; NM_021638; NM_198595; NM_001371090; NM_001371091
	NM_027373
	NP_001128119; NP_940997; NP_001358019; NP_001358020
	NP_081649; NP_001390348; NP_001390349; NP_001390350
	Wikidata
View/Edit Human	View/Edit Mouse

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.^[5]^[6]^[7]^[8]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029094 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.
^ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.
^ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
^ ^a ^b "Entrez Gene: AFAP1 actin filament associated protein 1".

External links

Human AFAP1 genome location and AFAP1 gene details page in the UCSC Genome Browser.

Ishida Y, Hadano S, Nagayama T, et al. (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p". Genomics. 22 (2): 302–12. doi:10.1006/geno.1994.1388. PMID 7545969.
Qian Y, Baisden JM, Westin EH, et al. (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity". Oncogene. 16 (17): 2185–95. doi:10.1038/sj.onc.1201753. PMID 9619827.
Guappone AC, Weimer T, Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif". Mol. Carcinog. 22 (2): 110–9. doi:10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q. PMID 9655255.
Qian Y, Baisden JM, Zot HG, et al. (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation". Exp. Cell Res. 255 (1): 102–13. doi:10.1006/excr.1999.4795. PMID 10666339.
Qian Y, Baisden JM, Cherezova L, et al. (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments". Mol. Biol. Cell. 13 (7): 2311–22. doi:10.1091/mbc.E01-12-0148. PMC 117315. PMID 12134071.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Dorfleutner A, Stehlik C, Zhang J, et al. (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells". J. Cell. Physiol. 213 (3): 740–9. CiteSeerX 10.1.1.636.3591. doi:10.1002/jcp.21143. PMID 17520695.

This article on a gene on human chromosome 4 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029094 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14755689-5] Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689.

[pmid11641786-6] Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786.

[pmid11607843-7] Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.

[entrez-8] "Entrez Gene: AFAP1 actin filament associated protein 1".

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[3]

[4]

[5]

[6]

[7]

[8]

References

External links

Further reading