NOL6

NOL6
Identifiers
Aliases	NOL6, NRAP, UTP22, bA311H10.1, nucleolar protein 6
External IDs	OMIM: 611532; MGI: 2140151; HomoloGene: 41505; GeneCards: NOL6; OMA:NOL6 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	33,473,930 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	41,124,455 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; olfactory zone of nasal mucosa; ; nasal epithelium; ; gastrocnemius muscle; ; skin of leg; ; right testis; ; left testis; ; tendon of biceps brachii; ; skin of abdomen; ; anterior pituitary;
	Top expressed in
	primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; tibiofemoral joint; ; gastrula; ; epiblast; ; right ventricle; ; yolk sac; ; cerebellar cortex; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; RNA binding;
Cellular component	condensed nuclear chromosome; small-subunit processome; nucleolus; mitochondrion; nucleus; CURI complex; chromosome; UTP-C complex; nucleoplasm;
Biological process	tRNA export from nucleus; rRNA processing;
	Sources:Amigo / QuickGO
Orthologs
	65083
	230082
	ENSG00000165271
	ENSMUSG00000028430
	Q9H6R4
	Q8R5K4
	NM_139235; NM_022917; NM_130793
	NM_139236; NM_139237
	NP_075068; NP_631981
	NP_631982
	Wikidata
View/Edit Human	View/Edit Mouse

Nucleolar protein 6 is a protein that in humans is encoded by the NOL6 gene.^[5]^[6]^[7]

The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165271 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028430 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Utama B, Kennedy D, Ru K, Mattick JS (Mar 2002). "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans". Genes Cells. 7 (2): 115–32. doi:10.1046/j.1356-9597.2001.00507.x. PMID 11895476.
^ Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.
^ ^a ^b "Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated)".

Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
Scherl A, Couté Y, Déon C, et al. (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165271 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000028430 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11895476-5] Utama B, Kennedy D, Ru K, Mattick JS (Mar 2002). "Isolation and characterization of a new nucleolar protein, Nrap, that is conserved from yeast to humans". Genes Cells. 7 (2): 115–32. doi:10.1046/j.1356-9597.2001.00507.x. PMID 11895476.

[pmid15590835-6] Bernstein KA, Gallagher JE, Mitchell BM, Granneman S, Baserga SJ (Dec 2004). "The small-subunit processome is a ribosome assembly intermediate". Eukaryot Cell. 3 (6): 1619–26. doi:10.1128/EC.3.6.1619-1626.2004. PMC 539036. PMID 15590835.

[entrez-7] "Entrez Gene: NOL6 nucleolar protein family 6 (RNA-associated)".

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References

Further reading