METTL3

METTL3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5IL0, 5IL2, 5IL1, 5K7M, 5K7U, 5K7W
Identifiers
Aliases	METTL3, IME4, M6A, MT-A70, Spo8, methyltransferase like 3, hmethyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
External IDs	OMIM: 612472; MGI: 1927165; HomoloGene: 10501; GeneCards: METTL3; OMA:METTL3 - orthologs
Gene location (Human) Chr. Chromosome 14 (human) Band 14q11.2 Start 21,498,133 bp End 21,511,342 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 C2 Start 52,532,298 bp End 52,542,585 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube right hemisphere of cerebellum body of uterus left lobe of thyroid gland left ovary right ovary right lobe of thyroid gland body of pancreas tibial nerve canal of the cervix Top expressed in embryo neural layer of retina saccule primary oocyte Paneth cell primitive streak otic placode embryo epithelium of lens facial motor nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function methyltransferase activity transferase activity RNA binding RNA methyltransferase activity mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity mRNA binding S-adenosyl-L-methionine binding protein heterodimerization activity protein binding mRNA (N6-adenosine)-methyltransferase activity Cellular component RNA N6-methyladenosine methyltransferase complex nucleoplasm nuclear speck nucleus cytoplasm Biological process rhythmic process mRNA processing positive regulation of cap-independent translational initiation stem cell population maintenance methylation mRNA methylation mRNA destabilization circadian rhythm primary miRNA processing adenosine to inosine editing RNA methylation mRNA splicing, via spliceosome mRNA catabolic process forebrain radial glial cell differentiation cellular response to UV gliogenesis regulation of T cell differentiation negative regulation of Notch signaling pathway regulation of meiotic cell cycle endothelial to hematopoietic transition regulation of hematopoietic stem cell differentiation cellular response to DNA damage stimulus spermatogenesis cell differentiation dosage compensation by inactivation of X chromosome RNA metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56339 56335 Ensembl ENSG00000165819 ENSMUSG00000022160 UniProt Q86U44 Q8C3P7 RefSeq (mRNA) NM_019852 NM_019721 RefSeq (protein) NP_062826 NP_062695 Location (UCSC) Chr 14: 21.5 – 21.51 Mb Chr 14: 52.53 – 52.54 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

N6-adenosine-methyltransferase 70 kDa subunit (METTL3) is an enzyme that in humans is encoded by the METTL3 gene.

This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the post-transcriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine (m⁶A).

Further reading

• Beausoleil SA; Villén J; Gerber SA; et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Heilig R; Eckenberg R; Petit JL; et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. doi:10.1038/nature01348. PMID 12508121. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
• Bujnicki JM, Feder M, Radlinska M, Blumenthal RM (2003). "Structure prediction and phylogenetic analysis of a functionally diverse family of proteins homologous to the MT-A70 subunit of the human mRNA:m(6)A methyltransferase". J. Mol. Evol. 55 (4): 431–44. doi:10.1007/s00239-002-2339-8. PMID 12355263.
• Leach RA, Tuck MT (2001). "Expression of the mRNA (N6-adenosine)-methyltransferase S-adenosyl-L-methionine binding subunit mRNA in cultured cells". Int. J. Biochem. Cell Biol. 33 (10): 984–99. doi:10.1016/S1357-2725(01)00071-1. PMID 11470232.
• Bokar JA; Shambaugh ME; Polayes D; et al. (1998). "Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase". RNA. 3 (11): 1233–47. PMC 1369564. PMID 9409616. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)