From Wikipedia, the free encyclopedia
This article is about the human gene. For the submarine communications cable, see
SAT-2 . For the SAT II tests, see
SAT Subject Tests .
Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene .[ 5] [ 6] [ 7] metabolic glutamine /glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000141504 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000069835 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism" . Biochem J . 384 (Pt 1): 139–48. doi :10.1042/BJ20040790 . PMC 1134097 PMID 15283699 . ^ Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha" . J Biol Chem . 282 (32): 23572–80. doi :10.1074/jbc.M703504200 PMID 17558023 . ^ "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2" .^ Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate" . Cereb Cortex . 19 (5): 1092–106. doi :10.1093/cercor/bhn151 PMID 18832333 .
Further reading
Baek JH, Liu YV, McDonald KR, et al. (2008). "Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha" . J. Biol. Chem . 282 (46): 33358–66. doi :10.1074/jbc.M705627200 PMID 17875644 . Gornati R, Chini V, Rimoldi S, et al. (2007). "Evaluation of SAT-1, SAT-2 and GalNAcT-1 mRNA in colon cancer by real-time PCR". Mol. Cell. Biochem . 298 (1–2): 59–68. doi :10.1007/s11010-006-9350-0 . PMID 17119850 . Han BW, Bingman CA, Wesenberg GE, Phillips GN (2006). "Crystal structure of Homo sapiens thialysine Nepsilon-acetyltransferase (HsSSAT2) in complex with acetyl coenzyme A". Proteins . 64 (1): 288–93. doi :10.1002/prot.20967 . PMID 16596569 . Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. doi :10.1038/nature04209 . PMID 16189514 . Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715): 1621–5. doi :10.1126/science.1105776 . PMID 15761153 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Chen Y, Vujcic S, Liang P, et al. (2003). "Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase" . Biochem. J . 373 (Pt 3): 661–7. doi :10.1042/BJ20030734 . PMC 1223561 PMID 12803540 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 .
