SAT2

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SAT2
Protein SAT2 PDB 2bei.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SAT2, Sspermidine/spermine N1-acetyltransferase family member 2
External IDs MGI: 1916465 HomoloGene: 44215 GeneCards: SAT2
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_133491
NM_001320845
NM_001320846
NM_001320847

NM_026991

RefSeq (protein)

NP_001307774
NP_001307775
NP_001307776
NP_597998

NP_081267.1
NP_081267

Location (UCSC) Chr 17: 7.63 – 7.63 Mb Chr 11: 69.62 – 69.62 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Diamine acetyltransferase 2 is an enzyme that in humans is encoded by the SAT2 gene.[3][4][5] SAT2 maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate.[6]


References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Coleman CS, Stanley BA, Jones AD, Pegg AE (Nov 2004). "Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism". Biochem J. 384 (Pt 1): 139–48. doi:10.1042/BJ20040790. PMC 1134097Freely accessible. PMID 15283699. 
  4. ^ Baek JH, Liu YV, McDonald KR, Wesley JB, Hubbi ME, Byun H, Semenza GL (Aug 2007). "Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha". J Biol Chem. 282 (32): 23572–80. doi:10.1074/jbc.M703504200. PMID 17558023. 
  5. ^ "Entrez Gene: SAT2 spermidine/spermine N1-acetyltransferase 2". 
  6. ^ Jenstad M, Quazi AZ, Zilberter M, Haglerød C, Berghuis P, Saddique N, Goiny M, Buntup D, Davanger S, S Haug FM, Barnes CA, McNaughton BL, Ottersen OP, Storm-Mathisen J, Harkany T, Chaudhry FA (May 2009). "System A transporter SAT2 mediates replenishment of dendritic glutamate pools controlling retrograde signaling by glutamate.". Cereb Cortex. 19 (5): 1092–106. doi:10.1093/cercor/bhn151. PMID 18832333. 

Further reading[edit]