DEF6

DEF6
Identifiers
Aliases	DEF6, IBP, SLAT, SWAP70L, guanine nucleotide exchange factor, DEF6 guanine nucleotide exchange factor, IMD87
External IDs	OMIM: 610094; MGI: 1346328; HomoloGene: 11103; GeneCards: DEF6; OMA:DEF6 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	35,321,771 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	28,447,582 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; monocyte; ; spleen; ; lymph node; ; skin of abdomen; ; appendix; ; skin of leg; ; body of pancreas; ; bone marrow;
	Top expressed in
	thymus; ; granulocyte; ; mesenteric lymph nodes; ; submandibular gland; ; molar; ; lumbar spinal ganglion; ; bone marrow; ; stroma of bone marrow; ; spleen; ; lip;
	More reference expression data
	More reference expression data
Orthologs
	50619
	23853
	ENSG00000023892
	ENSMUSG00000002257
	Q9H4E7
	Q8C2K1
	NM_022047
	NM_027185
	NP_071330
	NP_081461
	Wikidata
View/Edit Human	View/Edit Mouse

Differentially expressed in FDCP 6 homolog is a protein that in humans is encoded by the DEF6 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000023892 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000002257 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM (May 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". The Journal of Biological Chemistry. 284 (18): 11882–91. doi:10.1074/jbc.M809712200. PMC 2673257. PMID 19251698.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)".

Oka T, Ihara S, Fukui Y (Jan 2007). "Cooperation of DEF6 with activated Rac in regulating cell morphology". The Journal of Biological Chemistry. 282 (3): 2011–8. doi:10.1074/jbc.M605153200. PMID 17121847.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Mavrakis KJ, McKinlay KJ, Jones P, Sablitzky F (Apr 2004). "DEF6, a novel PH-DH-like domain protein, is an upstream activator of the Rho GTPases Rac1, Cdc42, and RhoA". Experimental Cell Research. 294 (2): 335–44. doi:10.1016/j.yexcr.2003.12.004. PMID 15023524.
Gupta S, Fanzo JC, Hu C, Cox D, Jang SY, Lee AE, Greenberg S, Pernis AB (Oct 2003). "T cell receptor engagement leads to the recruitment of IBP, a novel guanine nucleotide exchange factor, to the immunological synapse". The Journal of Biological Chemistry. 278 (44): 43541–9. doi:10.1074/jbc.M308960200. PMID 12923183.
Gupta S, Lee A, Hu C, Fanzo J, Goldberg I, Cattoretti G, Pernis AB (Apr 2003). "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system". Human Immunology. 64 (4): 389–401. doi:10.1016/S0198-8859(03)00024-7. PMID 12651066.
Tanaka Y, Bi K, Kitamura R, Hong S, Altman Y, Matsumoto A, Tabata H, Lebedeva S, Bushway PJ, Altman A (Mar 2003). "SWAP-70-like adapter of T cells, an adapter protein that regulates early TCR-initiated signaling in Th2 lineage cells". Immunity. 18 (3): 403–14. doi:10.1016/S1074-7613(03)00054-2. PMID 12648457.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000023892 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000002257 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid19251698-5] Mehta H, Glogauer M, Bécart S, Altman A, Coggeshall KM (May 2009). "Adaptor protein SLAT modulates Fcgamma receptor-mediated phagocytosis in murine macrophages". The Journal of Biological Chemistry. 284 (18): 11882–91. doi:10.1074/jbc.M809712200. PMC 2673257. PMID 19251698.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[entrez-6] "Entrez Gene: DEF6 differentially expressed in FDCP 6 homolog (mouse)".

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References

Further reading