From Wikipedia, the free encyclopedia
Giantin or Golgin subfamily B member 1 is a protein that in humans is encoded by the GOLGB1 gene .[ 5] [ 6] [ 7] homodimer .
Interactions
GOLGB1 has been shown to interact with ACBD3 and with PLK3 .[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000173230 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034243 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Linstedt AD, Hauri HP (Nov 1993). "Giantin, a novel conserved Golgi membrane protein containing a cytoplasmic domain of at least 350 kDa" . Mol Biol Cell . 4 (7): 679–93. doi :10.1091/mbc.4.7.679 . PMC 300978 PMID 7691276 . ^ Oka T, Ungar D, Hughson FM, Krieger M (Apr 2004). "The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins" . Mol Biol Cell . 15 (5): 2423–35. doi :10.1091/mbc.E03-09-0699 . PMC 404034 PMID 15004235 . ^ "Entrez Gene: GOLGB1 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1" .^ Sohda, M; Misumi Y; Yamamoto A; Yano A; Nakamura N; Ikehara Y (Nov 2001). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin" . J. Biol. Chem . 276 (48): 45298–306. doi :10.1074/jbc.M108961200 ISSN 0021-9258 . PMID 11590181 .
Further reading
Sohda M, Misumi Y, Fujiwara T, et al. (1995). "Molecular cloning and sequence analysis of a human 372-kDA protein localized in the Golgi complex". Biochem. Biophys. Res. Commun . 205 (2): 1399–408. doi :10.1006/bbrc.1994.2821 . PMID 7802676 . Seelig HP, Schranz P, Schröter H, et al. (1994). "Macrogolgin--a new 376 kD Golgi complex outer membrane protein as target of antibodies in patients with rheumatic diseases and HIV infections". J. Autoimmun . 7 (1): 67–91. doi :10.1006/jaut.1994.1006 . PMID 8198703 . Sönnichsen B, Lowe M, Levine T, et al. (1998). "A role for giantin in docking COPI vesicles to Golgi membranes" . J. Cell Biol . 140 (5): 1013–21. doi :10.1083/jcb.140.5.1013 . PMC 2132694 PMID 9490716 . Linstedt AD, Jesch SA, Mehta A, et al. (2000). "Binding relationships of membrane tethering components. The giantin N terminus and the GM130 N terminus compete for binding to the p115 C terminus" . J. Biol. Chem . 275 (14): 10196–201. doi :10.1074/jbc.275.14.10196 PMID 10744704 . Dirac-Svejstrup AB, Shorter J, Waters MG, Warren G (2000). "Phosphorylation of the vesicle-tethering protein p115 by a casein kinase II-like enzyme is required for Golgi reassembly from isolated mitotic fragments" . J. Cell Biol . 150 (3): 475–88. doi :10.1083/jcb.150.3.475 . PMC 2175190 PMID 10931861 . Alvarez C, Garcia-Mata R, Hauri HP, Sztul E (2001). "The p115-interactive proteins GM130 and giantin participate in endoplasmic reticulum-Golgi traffic" . J. Biol. Chem . 276 (4): 2693–700. doi :10.1074/jbc.M007957200 PMID 11035033 . Sohda M, Misumi Y, Yamamoto A, et al. (2002). "Identification and characterization of a novel Golgi protein, GCP60, that interacts with the integral membrane protein giantin" . J. Biol. Chem . 276 (48): 45298–306. doi :10.1074/jbc.M108961200 PMID 11590181 . Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115" . J. Cell Biol . 157 (1): 45–62. doi :10.1083/jcb.200112127 . PMC 2173270 PMID 11927603 . Gillingham AK, Pfeifer AC, Munro S (2003). "CASP, the alternatively spliced product of the gene encoding the CCAAT-displacement protein transcription factor, is a Golgi membrane protein related to giantin" . Mol. Biol. Cell . 13 (11): 3761–74. doi :10.1091/mbc.E02-06-0349 . PMC 133590 PMID 12429822 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources" . Mol. Cell. Proteomics . 3 (4): 311–26. doi :10.1074/mcp.M300127-MCP200 PMID 14718574 . Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 PMID 15231748 . Breuza L, Halbeisen R, Jenö P, et al. (2004). "Proteomics of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membranes from brefeldin A-treated HepG2 cells identifies ERGIC-32, a new cycling protein that interacts with human Erv46" . J. Biol. Chem . 279 (45): 47242–53. doi :10.1074/jbc.M406644200 PMID 15308636 . Malsam J, Satoh A, Pelletier L, Warren G (2005). "Golgin tethers define subpopulations of COPI vesicles". Science . 307 (5712): 1095–8. doi :10.1126/science.1108061 . PMID 15718469 . Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell . 122 (6): 957–68. doi :10.1016/j.cell.2005.08.029 . hdl :11858/00-001M-0000-0010-8592-0 PMID 16169070 . Rosing M, Ossendorf E, Rak A, Barnekow A (2007). "Giantin interacts with both the small GTPase Rab6 and Rab1". Exp. Cell Res . 313 (11): 2318–25. doi :10.1016/j.yexcr.2007.03.031 . PMID 17475246 .
