PLK3

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PLK3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases PLK3, CNK, FNK, PRK, PLK-3, polo like kinase 3
External IDs MGI: 109604 HomoloGene: 20865 GeneCards: 1263
RNA expression pattern
PBB GE PLK3 204958 at tn.png

PBB GE PLK3 215462 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004073

NM_013807
NM_001313916

RefSeq (protein)

NP_004064.2

n/a

Location (UCSC) Chr 1: 44.8 – 44.81 Mb Chr 4: 117.13 – 117.13 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Polo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.[1][2]

Function[edit]

Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory domain. It may play a role in regulation of cell cycle progression and tumorigenesis.[1]

Interactions[edit]

PLK3 has been shown to interact with:

References[edit]

  1. ^ a b "Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)". 
  2. ^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). "Prk, a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J. Biol. Chem. 271 (32): 19402–8. doi:10.1074/jbc.271.32.19402. PMID 8702627. 
  3. ^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). "The physical association and phosphorylation of Cdc25C protein phosphatase by Prk". Oncogene 18 (44): 6029–36. doi:10.1038/sj.onc.1202983. PMID 10557092. 
  4. ^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). "Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways". Oncogene 21 (43): 6633–40. doi:10.1038/sj.onc.1205850. PMID 12242661. 
  5. ^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). "Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway". J. Biol. Chem. 276 (46): 43305–12. doi:10.1074/jbc.M106050200. PMID 11551930. 

Further reading[edit]