From Wikipedia, the free encyclopedia
PDZ and LIM domain protein 5 is a protein that in humans is encoded by the PDLIM5 gene .[ 5] [ 6]
The protein encoded by this gene is a LIM domain protein. LIM domains are cysteine-rich double zinc fingers composed of 50 to 60 amino acids that are involved in protein-protein interactions. LIM domain-containing proteins are scaffolds for the formation of multiprotein complexes. The proteins are involved in cytoskeleton organization, cell lineage specification, organ development, and oncogenesis. The encoded protein is also a member of the Enigma class of proteins, a family of proteins that possess a 100-amino acid PDZ domain in the N terminus and 1 to 3 LIM domains in the C terminus. Multiple transcript variants encoding different isoforms have been found for this gene, although not all of them have been fully characterized.[ 6]
Interactions
PDLIM5 has been shown to interact with PRKCB1 .[ 7]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000163110 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028273 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Wu M, Li Y, Ji C, Xu J, Zheng H, Zou X, Gu S, Lou Y, Xie Y, Mao Y (September 2004). "Cloning and identification of a novel human gene PDLIM5, a homolog of AD-associated neuronal thread protein (AD7c-NTP)". DNA Seq . 15 (2): 144–7. doi :10.1080/10425170310001656756 . PMID 15346770 .
^ a b "Entrez Gene: PDLIM5 PDZ and LIM domain 5" .
^ Kuroda, S; Tokunaga C; Kiyohara Y; Higuchi O; Konishi H; Mizuno K; Gill G N; Kikkawa U (December 1996). "Protein-protein interaction of zinc finger LIM domains with protein kinase C" . J. Biol. Chem . 271 (49): 31029–32. doi :10.1074/jbc.271.49.31029 . ISSN 0021-9258 . PMID 8940095 .
Further reading
Sudo K, Chinen K, Nakamura Y (1995). "2058 expressed sequence tags (ESTs) from a human fetal lung cDNA library". Genomics . 24 (2): 276–9. doi :10.1006/geno.1994.1616 . PMID 7698749 .
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Res . 6 (9): 791–806. doi :10.1101/gr.6.9.791 . PMID 8889548 .
Kuroda S; Tokunaga C; Kiyohara Y; et al. (1997). "Protein-protein interaction of zinc finger LIM domains with protein kinase C" . J. Biol. Chem . 271 (49): 31029–32. doi :10.1074/jbc.271.49.31029 . PMID 8940095 .
Ueki N; Seki N; Yano K; et al. (1999). "Isolation, tissue expression, and chromosomal assignment of a human LIM protein gene, showing homology to rat enigma homologue (ENH)" . J. Hum. Genet . 44 (4): 256–60. doi :10.1007/s100380050155 . PMID 10429367 .
Nakagawa N; Hoshijima M; Oyasu M; et al. (2000). "ENH, containing PDZ and LIM domains, heart/skeletal muscle-specific protein, associates with cytoskeletal proteins through the PDZ domain". Biochem. Biophys. Res. Commun . 272 (2): 505–12. doi :10.1006/bbrc.2000.2787 . PMID 10833443 .
Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95. doi :10.1101/gr.143000 . PMC 310948 . PMID 11076863 .
Wiemann S; Weil B; Wellenreuther R; et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35. doi :10.1101/gr.GR1547R . PMC 311072 . PMID 11230166 .
Simpson JC; Wellenreuther R; Poustka A; et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92. doi :10.1093/embo-reports/kvd058 . PMC 1083732 . PMID 11256614 .
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .
Maeno-Hikichi Y; Chang S; Matsumura K; et al. (2003). "A PKC epsilon-ENH-channel complex specifically modulates N-type Ca2+ channels". Nat. Neurosci . 6 (5): 468–75. doi :10.1038/nn1041 . PMID 12665800 .
Iwamoto K; Kakiuchi C; Bundo M; et al. (2004). "Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders" . Mol. Psychiatry . 9 (4): 406–16. doi :10.1038/sj.mp.4001437 . PMID 14743183 .
Petroziello J; Yamane A; Westendorf L; et al. (2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer" . Oncogene . 23 (46): 7734–45. doi :10.1038/sj.onc.1207921 . PMID 15334068 .
Iwamoto K; Bundo M; Washizuka S; et al. (2004). "Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia" . J. Hum. Genet . 49 (5): 227–31. doi :10.1007/s10038-004-0136-5 . PMID 15362566 .
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Wiemann S; Arlt D; Huber W; et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136–44. doi :10.1101/gr.2576704 . PMC 528930 . PMID 15489336 .
Niederländer N, Fayein NA, Auffray C, Pomiès P (2005). "Characterization of a new human isoform of the enigma homolog family specifically expressed in skeletal muscle". Biochem. Biophys. Res. Commun . 325 (4): 1304–11. doi :10.1016/j.bbrc.2004.10.178 . PMID 15555569 .
Kato T; Iwayama Y; Kakiuchi C; et al. (2005). "Gene expression and association analyses of LIM (PDLIM5) in bipolar disorder and schizophrenia" . Mol. Psychiatry . 10 (11): 1045–55. doi :10.1038/sj.mp.4001719 . PMID 16044170 .
Rual JF; Venkatesan K; Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 .
Horiuchi Y; Arai M; Niizato K; et al. (2006). "A polymorphism in the PDLIM5 gene associated with gene expression and schizophrenia". Biol. Psychiatry . 59 (5): 434–9. doi :10.1016/j.biopsych.2005.07.041 . PMID 16213469 .
PDB gallery
1wf7 : Solution structure of the PDZ domain of Enigma homologue protein
2dar : Solution structure of first LIM domain of Enigma-like PDZ and LIM domains protein
2uzc : STRUCTURE OF HUMAN PDLIM5 IN COMPLEX WITH THE C-TERMINAL PEPTIDE OF HUMAN ALPHA-ACTININ-1