BMF (gene)

BMF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2VOG
Identifiers
Aliases	BMF, Bcl2 modifying factor
External IDs	OMIM: 606266; MGI: 2176433; HomoloGene: 14130; GeneCards: BMF; OMA:BMF - orthologs
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 40,087,890 bp End 40,108,892 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 118,359,238 bp End 118,380,168 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte bone marrow cells granulocyte islet of Langerhans right lobe of thyroid gland left lobe of thyroid gland gallbladder spleen appendix duodenum Top expressed in external carotid artery internal carotid artery medullary collecting duct hand trigeminal ganglion left lung lobe vas deferens superior cervical ganglion utricle prostate More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component mitochondrial outer membrane cytosol plasma membrane acrosomal vesicle myosin complex Biological process positive regulation of protein homooligomerization positive regulation of release of cytochrome c from mitochondria anoikis positive regulation of intrinsic apoptotic signaling pathway protein insertion into mitochondrial membrane involved in apoptotic signaling pathway apoptotic process positive regulation of apoptotic process negative regulation of autophagy cellular response to UV Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90427 171543 Ensembl ENSG00000104081 ENSMUSG00000040093 UniProt Q96LC9 Q91ZE9 RefSeq (mRNA) NM_001003940 NM_001003942 NM_001003943 NM_033503 NM_138313 NM_001311140 NM_001331221 RefSeq (protein) NP_001003940 NP_001003942 NP_001003943 NP_277038 NP_001298069 NP_001318150 NP_612186 Location (UCSC) Chr 15: 40.09 – 40.11 Mb Chr 2: 118.36 – 118.38 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.

Interactions

BMF (gene) has been shown to interact with Bcl-2 and DYNLL2.

Further reading

• Hattori A, Okumura K, Nagase T, et al. (2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lei K, Davis RJ (2003). "JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2432–7. doi:10.1073/pnas.0438011100. PMC 151358. PMID 12591950.
• Day CL, Puthalakath H, Skea G, et al. (2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895. PMID 14561217.
• Morales AA, Olsson A, Celsing F, et al. (2004). "Expression and transcriptional regulation of functionally distinct Bmf isoforms in B-chronic lymphocytic leukemia cells". Leukemia. 18 (1): 41–7. doi:10.1038/sj.leu.2403183. PMID 14574334.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Chen L, Willis SN, Wei A, et al. (2005). "Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function". Mol. Cell. 17 (3): 393–403. doi:10.1016/j.molcel.2004.12.030. PMID 15694340.
• Kuwana T, Bouchier-Hayes L, Chipuk JE, et al. (2005). "BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly". Mol. Cell. 17 (4): 525–35. doi:10.1016/j.molcel.2005.02.003. PMID 15721256.
• Soung YH, Lee JW, Park WS, et al. (2006). "BH3 domain mutation of proapoptotic genes Bad, Bmf and Bcl-G is rare in transitional cell carcinomas of the urinary bladder". Pathology. 38 (1): 33–4. doi:10.1080/00313020500455811. PMID 16484005.
• Zhang Y, Adachi M, Kawamura R, et al. (2007). "Bmf contributes to histone deacetylase inhibitor-mediated enhancing effects on apoptosis after ionizing radiation". Apoptosis. 11 (8): 1349–57. doi:10.1007/s10495-006-8266-1. PMID 16830229.
• Schmelzle T, Mailleux AA, Overholtzer M, et al. (2007). "Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis". Proc. Natl. Acad. Sci. U.S.A. 104 (10): 3787–92. doi:10.1073/pnas.0700115104. PMC 1820662. PMID 17360431.
• Yoo NJ, Soung YH, Lee SH, et al. (2007). "Mutational analysis of the BH3 domains of proapoptotic Bcl-2 family genes Bad, Bmf and Bcl-G in laryngeal squamous cell carcinomas". Tumori. 93 (2): 195–7. PMID 17557568.

External links

• Human BMF genome location and BMF gene details page in the UCSC Genome Browser.