BMF (gene)

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BMF
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BMF, Bcl2 modifying factor
External IDs MGI: 2176433 HomoloGene: 14130 GeneCards: BMF
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003940
NM_001003942
NM_001003943
NM_033503

NM_138313
NM_001311140
NM_001331221

RefSeq (protein)

NP_001003940
NP_001003942
NP_001003943
NP_277038

NP_612186.2
NP_001298069
NP_001318150
NP_612186

Location (UCSC) Chr 15: 40.09 – 40.11 Mb Chr 2: 118.53 – 118.55 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Bcl-2-modifying factor is a protein that in humans is encoded by the BMF gene.[3][4]

The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified.[4]

Interactions[edit]

BMF (gene) has been shown to interact with Bcl-2[3] and DYNLL2.[3][5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b c Puthalakath H, Villunger A, O'Reilly LA, Beaumont JG, Coultas L, Cheney RE, Huang DC, Strasser A (Sep 2001). "Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis". Science. 293 (5536): 1829–32. doi:10.1126/science.1062257. PMID 11546872. 
  4. ^ a b "Entrez Gene: BMF Bcl2 modifying factor". 
  5. ^ Day, Catherine L; Puthalakath Hamsa; Skea Gretchen; Strasser Andreas; Barsukov Igor; Lian Lu-Yun; Huang David C S; Hinds Mark G (Feb 2004). "Localization of dynein light chains 1 and 2 and their pro-apoptotic ligands". Biochem. J. England. 377 (Pt 3): 597–605. doi:10.1042/BJ20031251. PMC 1223895Freely accessible. PMID 14561217. 

External links[edit]

Further reading[edit]