GRAP2

GRAP2
Identifiers
Aliases	GRAP2, GADS, GRAP-2, GRB2L, GRBLG, GRID, GRPL, GrbX, Grf40, Mona, P38, GRB2-related adaptor protein 2, GRB2 related adaptor protein 2
External IDs	OMIM: 604518; MGI: 1333842; HomoloGene: 21007; GeneCards: GRAP2; OMA:GRAP2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	39,973,721 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	80,537,055 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; thymus; ; lymph node; ; testicle; ; spleen; ; epithelium of colon; ; appendix; ; bone marrow cells;
	Top expressed in
	thymus; ; blood; ; spleen; ; yolk sac; ; embryo; ; mesenteric lymph nodes; ; granulocyte; ; genital tubercle; ; tail of embryo; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; non-membrane spanning protein tyrosine kinase activity; signaling receptor binding;
Cellular component	cytoplasm; cytosol; endosome; nucleus; extrinsic component of cytoplasmic side of plasma membrane;
Biological process	Fc-epsilon receptor signaling pathway; cell-cell signaling; T cell costimulation; Ras protein signal transduction; T cell receptor signaling pathway; positive regulation of signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway; cell migration; cell differentiation; peptidyl-tyrosine autophosphorylation; regulation of cell population proliferation; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	9402
	17444
	ENSG00000100351
	ENSMUSG00000042351
	O75791
	O89100
	NM_001291824; NM_001291825; NM_001291826; NM_001291828; NM_004810
	NM_001289442; NM_010815
	NP_001278753; NP_001278754; NP_001278755; NP_001278757; NP_004801
	NP_001276371; NP_034945
	Wikidata
View/Edit Human	View/Edit Mouse

GRB2-related adapter protein 2 also known as GRB2-related adaptor downstream of Shc (GADS) is a 37 kDa protein that in humans is encoded by the GRAP2 gene.^[5]^[6]^[7]

Function

This gene encodes a member of the GRB2/Sem5/Drk family. This member is an adaptor-like protein involved in leukocyte-specific protein-tyrosine kinase signaling. Like its related family member, GRB2-related adaptor protein (GRAP), this protein contains an SH2 domain flanked by two SH3 domains. This protein interacts with other proteins, such as GRB2-associated binding protein 1 (GAB1) and the SLP-76 leukocyte protein (LCP2), through its SH3 domains. Transcript variants utilizing alternative polyA sites exist.^[7]

Interactions

GRAP2 has been shown to interact with:

CCNDBP1,^[8]
CD28,^[9]
Linker of activated T cells,^[6]^[10]
Lymphocyte cytosolic protein 2^[6]^[9]^[11]^[10]
MAP4K1,^[12] and
STAMBP.^[6]^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100351 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042351 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Qiu M, Hua S, Agrawal M, Li G, Cai J, Chan E, Zhou H, Luo Y, Liu M (Dec 1998). "Molecular cloning and expression of human grap-2, a novel leukocyte-specific SH2- and SH3-containing adaptor-like protein that binds to gab-1". Biochemical and Biophysical Research Communications. 253 (2): 443–7. doi:10.1006/bbrc.1998.9795. PMID 9878555.
^ ^a ^b ^c ^d Asada H, Ishii N, Sasaki Y, Endo K, Kasai H, Tanaka N, Takeshita T, Tsuchiya S, Konno T, Sugamura K (May 1999). "Grf40, A novel Grb2 family member, is involved in T cell signaling through interaction with SLP-76 and LAT". The Journal of Experimental Medicine. 189 (9): 1383–90. doi:10.1084/jem.189.9.1383. PMC 2193052. PMID 10224278.
^ ^a ^b "Entrez Gene: GRAP2 GRB2-related adaptor protein 2".
^ Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M (Jul 2000). "GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity". The Journal of Biological Chemistry. 275 (27): 20942–8. doi:10.1074/jbc.M002598200. PMID 10801854.
^ ^a ^b Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA (Jun 2000). "GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28". Journal of Immunology. 164 (11): 5805–14. doi:10.4049/jimmunol.164.11.5805. PMID 10820259.
^ ^a ^b Liu SK, Fang N, Koretzky GA, McGlade CJ (Jan 1999). "The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors". Current Biology. 9 (2): 67–75. doi:10.1016/s0960-9822(99)80017-7. PMID 10021361.
^ ^a ^b Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Ma W, Xia C, Ling P, Qiu M, Luo Y, Tan TH, Liu M (Mar 2001). "Leukocyte-specific adaptor protein Grap2 interacts with hematopoietic progenitor kinase 1 (HPK1) to activate JNK signaling pathway in T lymphocytes". Oncogene. 20 (14): 1703–14. doi:10.1038/sj.onc.1204224. PMID 11313918.