PIGC

PIGC
Identifiers
Aliases	PIGC, GPI2, phosphatidylinositol glycan anchor biosynthesis class C, MRT62, GPIBD16
External IDs	OMIM: 601730; MGI: 1914542; HomoloGene: 7109; GeneCards: PIGC; OMA:PIGC - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	172,444,086 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	161,801,004 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; skin of leg; ; skin of abdomen; ; islet of Langerhans; ; monocyte; ; skin of thigh; ; nipple; ; body of pancreas; ; bone marrow; ; hair follicle;
	Top expressed in
	seminal vesicula; ; cornea; ; renal corpuscle; ; calvaria; ; epithelium of lens; ; temporal muscle; ; upper arm; ; molar; ; primary oocyte; ; triceps brachii muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; phosphatidylinositol N-acetylglucosaminyltransferase activity; catalytic activity; glycosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex; endoplasmic reticulum; membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane;
	Sources:Amigo / QuickGO
Orthologs
	5279
	67292
	ENSG00000135845
	ENSMUSG00000026698
	Q92535
	Q9CXR4
	NM_153747; NM_002642
	NM_001039045; NM_026078
	NP_002633; NP_714969
	NP_001034134; NP_080354
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphatidylinositol N-acetylglucosaminyltransferase subunit C is an enzyme that in humans is encoded by the PIGC gene.^[5]^[6]^[7]

This gene encodes an endoplasmic reticulum associated protein that is involved in glycosylphosphatidylinositol (GPI) lipid anchor biosynthesis. The GPI lipid anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. The encoded protein is one subunit of the GPI N-acetylglucosaminyl (GlcNAc) transferase that transfers GlcNAc to phosphatidylinositol (PI) on the cytoplasmic side of the endoplasmic reticulum. Two alternatively spliced transcripts that encode the same protein have been found for this gene. A pseudogene on chromosome 11 has also been characterized.^[7]

Interactions

PIGC has been shown to interact with PIGQ.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135845 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026698 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Inoue N, Watanabe R, Takeda J, Kinoshita T (Oct 1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2". Biochem Biophys Res Commun. 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613.
^ Hong Y, Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Nov 1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1". Genomics. 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057.
^ ^a ^b "Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C".
^ Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4). ENGLAND: 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366.

Eisenhaber B, Maurer-Stroh S, Novatchkova M, et al. (2003). "Enzymes and auxiliary factors for GPI lipid anchor biosynthesis and post-translational transfer to proteins". BioEssays. 25 (4): 367–85. doi:10.1002/bies.10254. PMID 12655644.
Adams MD, Kerlavage AR, Fleischmann RD, et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Watanabe R, Kinoshita T, Masaki R, et al. (1996). "PIG-A and PIG-H, which participate in glycosylphosphatidylinositol anchor biosynthesis, form a protein complex in the endoplasmic reticulum". J. Biol. Chem. 271 (43): 26868–75. doi:10.1074/jbc.271.43.26868. PMID 8900170.
Watanabe R, Inoue N, Westfall B, et al. (1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4): 877–85. doi:10.1093/emboj/17.4.877. PMC 1170437. PMID 9463366.
Watanabe R, Murakami Y, Marmor MD, et al. (2000). "Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2". EMBO J. 19 (16): 4402–11. doi:10.1093/emboj/19.16.4402. PMC 302040. PMID 10944123.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135845 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026698 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8806613-5] Inoue N, Watanabe R, Takeda J, Kinoshita T (Oct 1996). "PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2". Biochem Biophys Res Commun. 226 (1): 193–9. doi:10.1006/bbrc.1996.1332. PMID 8806613.

[pmid9325057-6] Hong Y, Ohishi K, Inoue N, Endo Y, Fujita T, Takeda J, Kinoshita T (Nov 1997). "Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1". Genomics. 44 (3): 347–9. doi:10.1006/geno.1997.4893. PMID 9325057.

[entrez-7] "Entrez Gene: PIGC phosphatidylinositol glycan anchor biosynthesis, class C".

[pmid9463366-8] Watanabe, R; Inoue N; Westfall B; Taron C H; Orlean P; Takeda J; Kinoshita T (Feb 1998). "The first step of glycosylphosphatidylinositol biosynthesis is mediated by a complex of PIG-A, PIG-H, PIG-C and GPI1". EMBO J. 17 (4). ENGLAND: 877–85. doi:10.1093/emboj/17.4.877. ISSN 0261-4189. PMC 1170437. PMID 9463366.

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Interactions

References

Further reading