Ran-specific binding protein 1 is an enzyme that in humans is encoded by the RANBP1gene.[5][6][7]
Ran/TC4-binding protein, RanBP1, interacts specifically with GTP-charged RAN. RANBP1 encodes a 23-kD protein that binds to RAN complexed with GTP but not GDP. RANBP1 does not activate GTPase activity of RAN but does markedly increase GTP hydrolysis by the RanGTPase-activating protein (RANGAP1). The RANBP1 cDNA encodes a 201-amino acid protein that is 92% similar to its mouse homolog. In both mammalian cells and in yeast, RANBP1 acts as a negative regulator of RCC1 by inhibiting RCC1-stimulated guanine nucleotide release from RAN.[7]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (August 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/TC4, inhibits RCC1 via Ran/TC4". Mol Gen Genet. 247 (6): 661–9. doi:10.1007/BF00290397. PMID7616957.
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Coutavas E; Ren M; Oppenheim JD; et al. (1994). "Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4". Nature. 366 (6455): 585–7. Bibcode:1993Natur.366..585C. doi:10.1038/366585a0. PMID8255297. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
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