From Wikipedia, the free encyclopedia
2-oxoglutarate and iron-dependent oxygenase domain containing 1 , also known as OGFOD1, is a human gene .[ 5]
Model organisms
Model organisms have been used in the study of OGFOD1 function. A conditional knockout mouse line, called Ogfod1tm1a(KOMP)Wtsi [ 10] [ 11] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[ 12] [ 13] [ 14] phenotypic screen to determine the effects of deletion.[ 8] [ 15] homozygous mutant adult mice, however no significant abnormalities were observed.[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000087263 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033009 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: 2-oxoglutarate and iron-dependent oxygenase domain containing 1" . Retrieved 2011-08-30 .^ "Salmonella infection data for Ogfod1" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Ogfod1" . Wellcome Trust Sanger Institute.^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–42. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (Jun 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biology . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . {{cite journal }}: CS1 maint: unflagged free DOI (link )
Further reading
Saito K, Adachi N, Koyama H, Matsushita M (Aug 2010). "OGFOD1, a member of the 2-oxoglutarate and iron dependent dioxygenase family, functions in ischemic signaling". FEBS Letters . 584 (15): 3340–7. doi :10.1016/j.febslet.2010.06.015 . PMID 20579638 . Nagase T, Kikuno R, Nakayama M, Hirosawa M, Ohara O (Aug 2000). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 7 (4): 273–81. doi :10.1093/dnares/7.4.271 PMID 10997877 . Wehner KA, Schütz S, Sarnow P (Apr 2010). "OGFOD1, a novel modulator of eukaryotic translation initiation factor 2alpha phosphorylation and the cellular response to stress" . Molecular and Cellular Biology . 30 (8): 2006–16. doi :10.1128/MCB.01350-09 . PMC 2849474 PMID 20154146 . Barbe L, Lundberg E, Oksvold P, Stenius A, Lewin E, Björling E, Asplund A, Pontén F, Brismar H, Uhlén M, Andersson-Svahn H (Mar 2008). "Toward a confocal subcellular atlas of the human proteome" . Molecular & Cellular Proteomics . 7 (3): 499–508. doi :10.1074/mcp.M700325-MCP200 PMID 18029348 .
