From Wikipedia, the free encyclopedia
Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene.[ 5] [ 6] [ 7] [ 8]
MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID .[ 9]
Clinical significance
MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis.[ 9]
Variants of the MTCH2 gene may be associated with obesity .[ 10] [ 9]
See also
References
^ a b c ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha" . Mol. Cell. Biol . 25 (11): 4579–90. doi :10.1128/MCB.25.11.4579-4590.2005 . PMC 1140633 PMID 15899861 . ^ Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". J. Bioenerg. Biomembr . 37 (3): 113–9. doi :10.1007/s10863-005-6222-3 . PMID 16167168 . ^ Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?" . Apoptosis . 12 (5): 869–76. doi :10.1007/s10495-007-0748-2 PMID 17453157 . ^ Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, Li H, Leung CH, Zhu Y, Wei CL, Hooi SC, Miller L, Tan P (2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers" . PLOS Genet . 4 (7): e1000129. doi :10.1371/journal.pgen.1000129 . PMC 2444049 PMID 18636107 . CS1 maint: unflagged free DOI (link ) ^ a b c Gross A (2016). "BCL-2 family proteins as regulators of mitochondria metabolism" . Biochimica et Biophysica Acta 1857 (8): 1243–1246. doi :10.1016/j.bbabio.2016.01.017 PMID 26827940 . ^ Renström F, Payne F, Nordström A, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden" . Hum. Mol. Genet . 18 (8): 1489–96. doi :10.1093/hmg/ddp041 . PMC 2664142 PMID 19164386 .
Further reading
Yerushalmi GM, Leibowitz-Amit R, Shaharabany M, Tsarfaty I (2002). "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization" . Neoplasia . 4 (6): 510–22. doi :10.1038/sj.neo.7900272 . PMC 1503665 PMID 12407445 . Haupt A, Thamer C, Heni M, et al. (2009). "Novel Obesity Risk Loci Do Not Determine Distribution of Body Fat Depots: A Whole-body MRI/MRS study". Obesity (Silver Spring) . 18 (6): 1212–1217. doi :10.1038/oby.2009.413 . PMID 19910938 . Albers M, Kranz H, Kober I, et al. (2005). "Automated yeast two-hybrid screening for nuclear receptor-interacting proteins" . Mol. Cell. Proteomics . 4 (2): 205–13. doi :10.1074/mcp.M400169-MCP200 PMID 15604093 . Willer CJ, Speliotes EK, Loos RJ, et al. (2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation" . Nat. Genet . 41 (1): 25–34. doi :10.1038/ng.287 . PMC 2695662 PMID 19079261 . Li S, Zhao JH, Luan J, et al. (2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies" . Am. J. Clin. Nutr . 91 (1): 184–90. doi :10.3945/ajcn.2009.28403 PMID 19812171 . Brandys MK, van Elburg AA, Loos RJ, et al. (2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". Am. J. Med. Genet. B Neuropsychiatr. Genet . 153B (2): 695–9. doi :10.1002/ajmg.b.31026 . PMID 19746409 . Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56. doi :10.1016/S0378-1119(97)00411-3 . PMID 9373149 . Zhang QH, Ye M, Wu XY, et al. (2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells" . Genome Res . 10 (10): 1546–60. doi :10.1101/gr.140200 . PMC 310934 PMID 11042152 . Bauer F, Elbers CC, Adan RA, et al. (2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference" . Am. J. Clin. Nutr . 90 (4): 951–9. doi :10.3945/ajcn.2009.27781 PMID 19692490 . Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 PMID 15489334 . Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4. doi :10.1016/0378-1119(94)90802-8 . PMID 8125298 . Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 PMID 12477932 . He M, Cornelis MC, Franks PW, et al. (2010). "Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus" . Arterioscler. Thromb. Vasc. Biol . 30 (2): 327–32. doi :10.1161/ATVBAHA.109.196196 . PMC 3061473 PMID 19910641 . Hotta K, Nakamura M, Nakamura T, et al. (2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population" . J. Hum. Genet . 54 (12): 727–31. doi :10.1038/jhg.2009.106 PMID 19851340 .
