HIST1H2BK

H2BC12
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CV5
Identifiers
Aliases	H2BC12, H2B/S, H2BFAiii, H2BFT, H2BK, histone cluster 1, H2bk, histone cluster 1 H2B family member k, H2B clustered histone 12, HIST1H2BK
External IDs	OMIM: 615045; MGI: 2448399; HomoloGene: 135980; GeneCards: H2BC12; OMA:H2BC12 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	27,146,855 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	22,220,515 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; monocyte; ; blood; ; Achilles tendon; ; placenta; ; mucosa of transverse colon; ; spleen; ; gonad; ; prostate; ; uterine tube;
	Top expressed in
	uterus; ; zygote; ; secondary oocyte; ; primary oocyte; ; white adipose tissue; ; bone marrow; ; adrenal gland; ; spermatid; ; urinary bladder; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; molecular function;
Cellular component	nucleoplasm; nucleosome; nucleus; chromosome; extracellular space; cytosol;
Biological process	nucleosome assembly; innate immune response in mucosa; defense response to bacterium; protein ubiquitination; antimicrobial humoral immune response mediated by antimicrobial peptide;
	Sources:Amigo / QuickGO
Orthologs
	85236
	319184
	ENSG00000197903
	ENSMUSG00000062727
	O60814
	Q8CGP1
	NM_080593; NM_001312653
	NM_175665
	NP_001299582; NP_542160
	NP_783596
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2B type 1-K is a protein that in humans is encoded by the HIST1H2BK gene.^[5]^[6]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family. This gene is found in the histone microcluster on chromosome 6p21.33.^[6]

Interactions

HIST1H2BK has been shown to interact with HIRA.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000062727 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST1H2BK histone cluster 1, H2bk".
^ Lorain, S; Quivy J P; Monier-Gavelle F; Scamps C; Lécluse Y; Almouzni G; Lipinski M (Sep 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. 18 (9). UNITED STATES: 5546–56. doi:10.1128/MCB.18.9.5546. ISSN 0270-7306. PMC 109139. PMID 9710638.

Dobner T, Wolf I, Mai B, Lipp M (1992). "A novel divergently transcribed human histone H2A/H2B gene pair". DNA Seq. 1 (6): 409–13. doi:10.3109/10425179109020799. PMID 1768865.
Frohm M; Gunne H; Bergman AC; et al. (1996). "Biochemical and antibacterial analysis of human wound and blister fluid". Eur. J. Biochem. 237 (1): 86–92. doi:10.1111/j.1432-1033.1996.0086n.x. PMID 8620898. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional Activation of the Integrated Chromatin-Associated Human Immunodeficiency Virus Type 1 Promoter". Mol. Cell. Biol. 18 (5): 2535–44. doi:10.1128/mcb.18.5.2535. PMC 110633. PMID 9566873.
Lorain S; Quivy JP; Monier-Gavelle F; et al. (1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC 109139. PMID 9710638. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Albig W; Trappe R; Kardalinou E; et al. (1999). "The human H2A and H2B histone gene complement". Biol. Chem. 380 (1): 7–18. doi:10.1515/BC.1999.002. PMID 10064132. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Ahn J, Gruen JR (1999). "The genomic organization of the histone clusters on human 6p21.3". Mamm. Genome. 10 (7): 768–70. doi:10.1007/s003359901089. PMID 10384058.
Deng L; de la Fuente C; Fu P; et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones". Virology. 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Deng L; Wang D; de la Fuente C; et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA". Virology. 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Kim HS; Cho JH; Park HW; et al. (2002). "Endotoxin-neutralizing antimicrobial proteins of the human placenta". J. Immunol. 168 (5): 2356–64. doi:10.4049/jimmunol.168.5.2356. PMID 11859126. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Cheung WL; Ajiro K; Samejima K; et al. (2003). "Apoptotic phosphorylation of histone H2B is mediated by mammalian sterile twenty kinase". Cell. 113 (4): 507–17. doi:10.1016/S0092-8674(03)00355-6. PMID 12757711. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Tollin M; Bergman P; Svenberg T; et al. (2004). "Antimicrobial peptides in the first line defence of human colon mucosa". Peptides. 24 (4): 523–30. doi:10.1016/S0196-9781(03)00114-1. PMID 12860195. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Mungall AJ; Palmer SA; Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Howell SJ, Wilk D, Yadav SP, Bevins CL (2004). "Antimicrobial polypeptides of the human colonic epithelium". Peptides. 24 (11): 1763–70. doi:10.1016/j.peptides.2003.07.028. PMID 15019208.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Andersen JS; Lam YW; Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Tsunaka Y, Kajimura N, Tate S, Morikawa K (2005). "Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle". Nucleic Acids Res. 33 (10): 3424–34. doi:10.1093/nar/gki663. PMC 1150222. PMID 15951514.
Golebiowski F, Kasprzak KS (2007). "Inhibition of core histones acetylation by carcinogenic nickel(II)". Mol. Cell. Biochem. 279 (1–2): 133–9. doi:10.1007/s11010-005-8285-1. PMID 16283522.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197903 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000062727 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12408966-5] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-6] "Entrez Gene: HIST1H2BK histone cluster 1, H2bk".

[pmid9710638-7] Lorain, S; Quivy J P; Monier-Gavelle F; Scamps C; Lécluse Y; Almouzni G; Lipinski M (Sep 1998). "Core Histones and HIRIP3, a Novel Histone-Binding Protein, Directly Interact with WD Repeat Protein HIRA". Mol. Cell. Biol. 18 (9). UNITED STATES: 5546–56. doi:10.1128/MCB.18.9.5546. ISSN 0270-7306. PMC 109139. PMID 9710638.

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Interactions

References

Further reading