Parkin coregulated gene protein is a protein that in humans is encoded by the PACRGgene.[5][6]
This gene encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.[6]
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Agirre X; Román-Gómez J; Vázquez I; et al. (2006). "Abnormal methylation of the common PARK2 and PACRG promoter is associated with downregulation of gene expression in acute lymphoblastic leukemia and chronic myeloid leukemia". International Journal of Cancer. 118 (8): 1945–53. doi:10.1002/ijc.21584. PMID16287063. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Lesage S; Magali P; Lohmann E; et al. (2007). "Deletion of the parkin and PACRG gene promoter in early-onset parkinsonism". Human Mutation. 28 (1): 27–32. doi:10.1002/humu.20436. PMID17068781. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Taylor JM; Song YJ; Huang Y; et al. (2007). "Parkin Co-Regulated Gene (PACRG) is regulated by the ubiquitin-proteasomal system and is present in the pathological features of Parkinsonian diseases". Neurobiology of Disease. 27 (2): 238–47. doi:10.1016/j.nbd.2007.04.014. PMID17590346. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)
Udina IG; Kordicheva SIu; Pospelov LE; et al. (2007). "[Study of the polymorphic markers--the PARK2 and PACRG genes due to the incidence of pulmonary tuberculosis in two districts of the Republic of Tyva]". Problemy Tuberkuleza I Bolezneĭ Legkikh (7): 27–9. PMID17722288. {{cite journal}}: Unknown parameter |name-list-format= ignored (|name-list-style= suggested) (help)