This is an old revision of this page, as edited by Rjwilmsi(talk | contribs) at 15:43, 4 July 2020(Journal cites:, added 1 PMID, added 1 Bibcode). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.
Revision as of 15:43, 4 July 2020 by Rjwilmsi(talk | contribs)(Journal cites:, added 1 PMID, added 1 Bibcode)
Dickkopf-related protein 2 is a protein that in humans is encoded by the DKK2gene.[5][6]
This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway.
It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).[6]
Wu W, Glinka A, Delius H, Niehrs C (2001). "Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/beta-catenin signalling". Curr. Biol. 10 (24): 1611–4. doi:10.1016/S0960-9822(00)00868-X. PMID11137016.
Mao B, Wu W, Li Y, et al. (2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins". Nature. 411 (6835): 321–5. doi:10.1038/35077108. PMID11357136.