PHLDA1

PHLDA1
Identifiers
Aliases	PHLDA1, DT1P1B11, PHRIP, TDAG51, pleckstrin homology like domain family A member 1
External IDs	OMIM: 605335; MGI: 1096880; HomoloGene: 7203; GeneCards: PHLDA1; OMA:PHLDA1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	76,031,776 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	111,344,506 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; stromal cell of endometrium; ; ganglionic eminence; ; salivary gland; ; minor salivary glands; ; gallbladder; ; vagina; ; right lung; ; tibial nerve; ; upper lobe of left lung;
	Top expressed in
	parotid gland; ; submandibular gland; ; lacrimal gland; ; left lobe of liver; ; otic placode; ; lactiferous gland; ; crypt of lieberkuhn of small intestine; ; epithelium of stomach; ; granulocyte; ; stria vascularis;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; cytoplasmic vesicle; cytosol; nucleus; nucleolus;
Biological process	apoptotic process; FasL biosynthetic process; G2/M transition of mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	22822
	21664
	ENSG00000139289
	ENSMUSG00000020205
	Q8WV24
	Q62392
	NM_007350
	NM_009344
	NP_031376
	NP_033370
	Wikidata
View/Edit Human	View/Edit Mouse

Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.^[5]^[6]^[7]

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.^[7]

Interactions

PHLDA1 has been shown to interact with RPL14,^[8] EIF3D^[8] and PABPC4.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000139289 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020205 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res. 62 (20): 5920–9. PMID 12384558.
^ Toyoshima Y; Karas M; Yakar S; Dupont J; Lee Helman; LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem. 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619.
^ ^a ^b "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1".
^ ^a ^b ^c Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5). England: 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516.

Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). "Mapping and characterization of novel (CAG)n repeat cDNAs from adult human brain derived by the oligo capture method". Genomics. 46 (2): 174–82. doi:10.1006/geno.1997.5044. PMID 9417904.
Kuske MD, Johnson JP (2000). "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping". Cytogenet. Cell Genet. 89 (1–2): 1. doi:10.1159/000015575. PMID 10894922.
Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:10.1016/S0898-6568(01)00141-3. PMID 11369516.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hossain GS, van Thienen JV, Werstuck GH, et al. (2003). "TDAG51 Is Induced by Homocysteine, Promotes Detachment-mediated Programmed Cell Death, and Contributes to the Development of Atherosclerosis in Hyperhomocysteinemia". J. Biol. Chem. 278 (32): 30317–27. doi:10.1074/jbc.M212897200. PMID 12738777.
Oberg HH, Sipos B, Kalthoff H, et al. (2005). "Regulation of T-cell death-associated gene 51 (TDAG51) expression in human T-cells". Cell Death Differ. 11 (6): 674–84. doi:10.1038/sj.cdd.4401407. PMID 15002043.
Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004). "A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation". Gene. 338 (2): 197–207. doi:10.1016/j.gene.2004.05.006. PMID 15315823.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000139289 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020205 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12384558-5] Neef R, Kuske MA, Prols E, Johnson JP (Oct 2002). "Identification of the human PHLDA1/TDAG51 gene: down-regulation in metastatic melanoma contributes to apoptosis resistance and growth deregulation". Cancer Res. 62 (20): 5920–9. PMID 12384558.

[pmid15037619-6] Toyoshima Y; Karas M; Yakar S; Dupont J; Lee Helman; LeRoith D (Jun 2004). "TDAG51 mediates the effects of insulin-like growth factor I (IGF-I) on cell survival". J Biol Chem. 279 (24): 25898–904. doi:10.1074/jbc.M400661200. PMID 15037619.

[entrez-7] "Entrez Gene: PHLDA1 pleckstrin homology-like domain, family A, member 1".

[pmid11369516-8] Hinz, T; Flindt S; Marx A; Janssen O; Kabelitz D (May 2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5). England: 345–52. doi:10.1016/S0898-6568(01)00141-3. ISSN 0898-6568. PMID 11369516.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

Interactions

References

Further reading