Musgrave's opponents were Democratic state representative Angie Paccione and former Ronald ReaganUnited States Environmental Protection Agency appointee Eric Eidsness, a former Republican who entered the race as a Reform Party candidate. When Paccione entered the race in September 2005 the race was not widely regarded as competitive outside the Fourth District, but the Paccione campaign successfully raised nearly $2 million, and the results were relatively close. The Cook Report called it a toss-up late in the campaign.
Musgrave's close margin of victory gives her the distinction of receiving the lowest percentage of the vote of any member of Congress.