From Wikipedia, the free encyclopedia
Tubulin tyrosine ligase-like family, member 3 is a protein that in humans is encoded by the TTLL3 gene .[ 5]
Model organisms
Model organisms have been used in the study of TTLL3 function. A conditional knockout mouse line, called Ttll3tm1a(EUCOMM)Wtsi [ 10] [ 11] International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute .[ 12] [ 13] [ 14]
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[ 8] [ 15] mutant mice but no significant abnormalities were observed.[ 8]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000214021 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030276 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: Tubulin tyrosine ligase-like family, member 3" . Retrieved 2011-09-21 .^ "Salmonella infection data for Ttll3" . Wellcome Trust Sanger Institute.^ "Citrobacter infection data for Ttll3" . Wellcome Trust Sanger Institute.^ a b c Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica . 88 (S248). doi :10.1111/j.1755-3768.2010.4142.x . S2CID 85911512 . ^ Mouse Resources Portal , Wellcome Trust Sanger Institute.^ "International Knockout Mouse Consortium" .^ "Mouse Genome Informatics" .^ Skarnes, W. C.; Rosen, B.; West, A. P.; Koutsourakis, M.; Bushell, W.; Iyer, V.; Mujica, A. O.; Thomas, M.; Harrow, J.; Cox, T.; Jackson, D.; Severin, J.; Biggs, P.; Fu, J.; Nefedov, M.; De Jong, P. J.; Stewart, A. F.; Bradley, A. (2011). "A conditional knockout resource for the genome-wide study of mouse gene function" . Nature . 474 (7351): 337–342. doi :10.1038/nature10163 . PMC 3572410 PMID 21677750 . ^ Dolgin E (June 2011). "Mouse library set to be knockout" . Nature . 474 (7351): 262–3. doi :10.1038/474262a PMID 21677718 . ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell . 128 (1): 9–13. doi :10.1016/j.cell.2006.12.018 . PMID 17218247 . S2CID 18872015 . ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism" . Genome Biol . 12 (6): 224. doi :10.1186/gb-2011-12-6-224 . PMC 3218837 PMID 21722353 . {{cite journal }}: CS1 maint: unflagged free DOI (link )
Further reading
Trichet, V.; Ruault, M.; Roizès, G.; De Sario, A. (2000). "Characterization of the human tubulin tyrosine ligase-like 1 gene (TTLL1) mapping to 22q13.1". Gene . 257 (1): 109–117. doi :10.1016/S0378-1119(00)00383-8 . PMID 11054573 . Rogowski, K.; Juge, F. O.; Van Dijk, J.; Wloga, D.; Strub, J. M.; Levilliers, N.; Thomas, D.; Bré, M. H. L. N.; Van Dorsselaer, A.; Gaertig, J.; Janke, C. (2009). "Evolutionary Divergence of Enzymatic Mechanisms for Posttranslational Polyglycylation" (PDF) . Cell . 137 (6): 1076–1087. doi :10.1016/j.cell.2009.05.020 . PMID 19524510 . S2CID 953190 .
