TOMM70

TOMM70
Identifiers
Aliases	TOMM70, TOMM70A, Tom70, translocase of outer mitochondrial membrane 70
External IDs	OMIM: 606081; MGI: 106295; HomoloGene: 40112; GeneCards: TOMM70; OMA:TOMM70 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	100,401,089 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	56,977,068 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; glutes; ; Brodmann area 23; ; deltoid muscle; ; parotid gland; ; triceps brachii muscle; ; Skeletal muscle tissue of biceps brachii; ; Skeletal muscle tissue of rectus abdominis; ; Brodmann area 46; ; middle temporal gyrus;
	Top expressed in
	nucleus accumbens; ; olfactory tubercle; ; medullary collecting duct; ; globus pallidus; ; cingulate gyrus; ; amygdala; ; dorsomedial hypothalamic nucleus; ; Paneth cell; ; renal corpuscle; ; Region I of hippocampus proper;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein transmembrane transporter activity; protein binding;
Cellular component	mitochondrial outer membrane; extracellular exosome; integral component of membrane; mitochondrial outer membrane translocase complex; membrane; mitochondrion;
Biological process	macroautophagy; protein targeting to mitochondrion; protein transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9868
	28185
	ENSG00000154174
	ENSMUSG00000022752
	O94826
	Q9CZW5
	NM_014820
	NM_138599
	NP_055635
	NP_613065
	Wikidata
View/Edit Human	View/Edit Mouse

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.^[5]^[6]

The translocase of outer mitochondrial membrane (TOM) complex is a multisubunit complex involved in the recognition, unfolding, and translocation of preproteins into the mitochondria. See TIM17A (MIM 605057).[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000154174 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J, Munoz A (Dec 1999). "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions". J Neurochem. 73 (6): 2240–9. doi:10.1046/j.1471-4159.1999.0732240.x. PMID 10582581. S2CID 23008591.
^ ^a ^b "Entrez Gene: TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)".

Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
Edmonson AM, Mayfield DK, Vervoort V, et al. (2002). "Characterization of a human import component of the mitochondrial outer membrane, TOMM70A". Cell Commun. Adhes. 9 (1): 15–27. doi:10.1080/15419060212186. PMID 12200962.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Young JC, Hoogenraad NJ, Hartl FU (2003). "Molecular chaperones Hsp90 and Hsp70 deliver preproteins to the mitochondrial import receptor Tom70". Cell. 112 (1): 41–50. doi:10.1016/S0092-8674(02)01250-3. PMID 12526792.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Humphries AD, Streimann IC, Stojanovski D, et al. (2005). "Dissection of the mitochondrial import and assembly pathway for human Tom40". J. Biol. Chem. 280 (12): 11535–43. doi:10.1074/jbc.M413816200. PMID 15644312.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Chou CH, Lee RS, Yang-Yen HF (2006). "An Internal EELD Domain Facilitates Mitochondrial Targeting of Mcl-1 via a Tom70-dependent Pathway". Mol. Biol. Cell. 17 (9): 3952–63. doi:10.1091/mbc.E06-04-0319. PMC 1593170. PMID 16822835.
Fan AC, Bhangoo MK, Young JC (2006). "Hsp90 functions in the targeting and outer membrane translocation steps of Tom70-mediated mitochondrial import". J. Biol. Chem. 281 (44): 33313–24. doi:10.1074/jbc.M605250200. PMID 16968702.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000154174 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022752 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10582581-5] Alvarez-Dolado M, Gonzalez-Moreno M, Valencia A, Zenke M, Bernal J, Munoz A (Dec 1999). "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions". J Neurochem. 73 (6): 2240–9. doi:10.1046/j.1471-4159.1999.0732240.x. PMID 10582581. S2CID 23008591.

[entrez-6] "Entrez Gene: TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)".

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TOMM70

See also

References

Further reading