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VARS

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VARS1
Identifiers
AliasesVARS1, VARS, NDMSCA, valyl-tRNA synthetase 1, G7A, VARS2, valyl-tRNA synthetase
External IDsOMIM: 192150; MGI: 90675; HomoloGene: 4587; GeneCards: VARS1; OMA:VARS1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006295

NM_011690

RefSeq (protein)

NP_006286
NP_006286.1

NP_035820

Location (UCSC)Chr 6: 31.78 – 31.8 MbChr 17: 35.22 – 35.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Valyl-tRNA synthetase is an enzyme that in humans is encoded by the VARS gene.[5][6]

Function

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. The protein encoded by this gene belongs to class-I aminoacyl-tRNA synthetase family and is located in the class III region of the major histocompatibility complex.[6]

See also

References

  1. ^ a b c ENSG00000096171, ENSG00000231945, ENSG00000227686, ENSG00000204394, ENSG00000224264, ENSG00000231116 GRCh38: Ensembl release 89: ENSG00000226589, ENSG00000096171, ENSG00000231945, ENSG00000227686, ENSG00000204394, ENSG00000224264, ENSG00000231116Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000007029Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bonnefond L, Fender A, Rudinger-Thirion J, Giegé R, Florentz C, Sissler M (March 2005). "Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS". Biochemistry. 44 (12): 4805–16. doi:10.1021/bi047527z. PMID 15779907.
  6. ^ a b "Entrez Gene: VARS valyl-tRNA synthetase".

Further reading