TUBB

TUBB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3QNZ, 3QO0
Identifiers
Aliases	TUBB, CDCBM6, M40, OK/SW-cl.56, TUBB1, TUBB5, CSCSC1, tubulin beta class I
External IDs	OMIM: 191130; MGI: 107812; HomoloGene: 69099; GeneCards: TUBB; OMA:TUBB - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,725,538 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	36,149,198 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; ventricular zone; ; smooth muscle tissue; ; stromal cell of endometrium; ; appendix; ; ovary; ; left ovary; ; islet of Langerhans; ; placenta; ; right ovary;
	Top expressed in
	medial ganglionic eminence; ; saccule; ; otic placode; ; otic vesicle; ; tail of embryo; ; maxillary prominence; ; primitive streak; ; somite; ; mandibular prominence; ; hand;
	More reference expression data
	n/a
Gene ontology
Molecular function	GTPase activating protein binding; nucleotide binding; protein domain specific binding; protein-containing complex binding; GTP binding; structural molecule activity; structural constituent of cytoskeleton; protein binding; GTPase activity; MHC class I protein binding; ubiquitin protein ligase binding;
Cellular component	cell body; extracellular region; nuclear envelope lumen; cytoplasmic ribonucleoprotein granule; extracellular exosome; extracellular matrix; microtubule; cytoskeleton; nucleus; microtubule cytoskeleton; azurophil granule lumen; cytoplasm; membrane raft; protein-containing complex;
Biological process	cytoskeleton-dependent intracellular transport; spindle assembly; cell division; G2/M transition of mitotic cell cycle; cellular process or phenomenon; natural killer cell mediated cytotoxicity; microtubule-based process; neutrophil degranulation; ciliary basal body-plasma membrane docking; regulation of G2/M transition of mitotic cell cycle; microtubule cytoskeleton organization; mitotic cell cycle; regulation of synapse organization; cytoskeleton organization;
	Sources:Amigo / QuickGO
Orthologs
	203068
	22154
ENSG00000196230; ENSG00000232421; ENSG00000183311; ENSG00000224156; ENSG00000235067;
	ENSG00000232575; ENSG00000227739; ENSG00000229684
	ENSMUSG00000001525
	P07437; Q5SU16
	P99024
NM_001293212; NM_001293213; NM_001293214; NM_001293215; NM_001293216;
	NM_178014
	NM_011655
NP_001280141; NP_001280142; NP_001280143; NP_001280144; NP_001280145;
	NP_821133; NP_821133.1
	NP_035785
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin beta chain is a protein that in humans is encoded by the TUBB gene.^[5]^[6]^[7]

Interactions

TUBB has been shown to interact with NCOA6^[8] and SYT9.^[9]

References

^ ^a ^b ^c ENSG00000232421, ENSG00000183311, ENSG00000224156, ENSG00000235067, ENSG00000232575, ENSG00000227739, ENSG00000229684 GRCh38: Ensembl release 89: ENSG00000196230, ENSG00000232421, ENSG00000183311, ENSG00000224156, ENSG00000235067, ENSG00000232575, ENSG00000227739, ENSG00000229684 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001525 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Crabtree DV, Ojima I, Geng X, Adler AJ (Aug 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorganic & Medicinal Chemistry. 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633.
^ Volz A, Weiss E, Trowsdale J, Ziegler A (Jan 1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction". Human Genetics. 93 (1): 42–6. doi:10.1007/BF00218911. PMID 8270253. S2CID 7853030.
^ "Entrez Gene: TUBB tubulin, beta".
^ Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968.
^ Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

Berrieman HK, Lind MJ, Cawkwell L (Mar 2004). "Do beta-tubulin mutations have a role in resistance to chemotherapy?". The Lancet. Oncology. 5 (3): 158–64. doi:10.1016/S1470-2045(04)01411-1. PMID 15003198.
Horisberger MA (Aug 1992). "Interferon-induced human protein MxA is a GTPase which binds transiently to cellular proteins". Journal of Virology. 66 (8): 4705–9. doi:10.1128/JVI.66.8.4705-4709.1992. PMC 241296. PMID 1629950.
Wang D, Villasante A, Lewis SA, Cowan NJ (Nov 1986). "The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype". The Journal of Cell Biology. 103 (5): 1903–10. doi:10.1083/jcb.103.5.1903. PMC 2114403. PMID 3782288.
Lee MG, Lewis SA, Wilde CD, Cowan NJ (Jun 1983). "Evolutionary history of a multigene family: an expressed human beta-tubulin gene and three processed pseudogenes". Cell. 33 (2): 477–87. doi:10.1016/0092-8674(83)90429-4. PMID 6688039.
Hall JL, Dudley L, Dobner PR, Lewis SA, Cowan NJ (May 1983). "Identification of two human beta-tubulin isotypes". Molecular and Cellular Biology. 3 (5): 854–62. doi:10.1128/mcb.3.5.854. PMC 368608. PMID 6865944.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Kinnunen T, Kaksonen M, Saarinen J, Kalkkinen N, Peng HB, Rauvala H (Apr 1998). "Cortactin-Src kinase signaling pathway is involved in N-syndecan-dependent neurite outgrowth". The Journal of Biological Chemistry. 273 (17): 10702–8. doi:10.1074/jbc.273.17.10702. PMID 9553134.
Niethammer M, Valtschanoff JG, Kapoor TM, Allison DW, Weinberg RJ, Craig AM, Sheng M (Apr 1998). "CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90". Neuron. 20 (4): 693–707. doi:10.1016/S0896-6273(00)81009-0. PMID 9581762. S2CID 16068361.
Rasmussen RK, Ji H, Eddes JS, Moritz RL, Reid GE, Simpson RJ, Dorow DS (May 1998). "Two-dimensional electrophoretic analysis of mixed lineage kinase 2 N-terminal domain binding proteins". Electrophoresis. 19 (5): 809–17. doi:10.1002/elps.1150190535. PMID 9629920. S2CID 21204230.
Ciruela F, Robbins MJ, Willis AC, McIlhinney RA (Jan 1999). "Interactions of the C terminus of metabotropic glutamate receptor type 1alpha with rat brain proteins: evidence for a direct interaction with tubulin". Journal of Neurochemistry. 72 (1): 346–54. doi:10.1046/j.1471-4159.1999.0720346.x. PMID 9886087. S2CID 3923065.
Chau MF, Radeke MJ, de Inés C, Barasoain I, Kohlstaedt LA, Feinstein SC (Dec 1998). "The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains". Biochemistry. 37 (51): 17692–703. doi:10.1021/bi9812118. PMID 9922135.
Piredda L, Farrace MG, Lo Bello M, Malorni W, Melino G, Petruzzelli R, Piacentini M (Feb 1999). "Identification of 'tissue' transglutaminase binding proteins in neural cells committed to apoptosis". FASEB Journal. 13 (2): 355–64. doi:10.1096/fasebj.13.2.355. PMID 9973324. S2CID 16417170.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Feng Y, Hodge DR, Palmieri G, Chase DL, Longo DL, Ferris DK (Apr 1999). "Association of polo-like kinase with alpha-, beta- and gamma-tubulins in a stable complex". The Biochemical Journal. 339 (2): 435–42. doi:10.1042/0264-6021:3390435. PMC 1220175. PMID 10191277.
Martín L, Fanarraga ML, Aloria K, Zabala JC (Mar 2000). "Tubulin folding cofactor D is a microtubule destabilizing protein". FEBS Letters. 470 (1): 93–5. doi:10.1016/S0014-5793(00)01293-X. PMID 10722852. S2CID 35012741.
Tarazona R, López-Lluch G, Galiani MD, Aguado E, Barahona F, Solana R, Peña J (Dec 2000). "HLA-B2702 (77-83/83-77) peptide binds to beta-tubulin on human NK cells and blocks their cytotoxic capacity". Journal of Immunology. 165 (12): 6776–82. doi:10.4049/jimmunol.165.12.6776. PMID 11120798.
Bonnet C, Boucher D, Lazereg S, Pedrotti B, Islam K, Denoulet P, Larcher JC (Apr 2001). "Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation". The Journal of Biological Chemistry. 276 (16): 12839–48. doi:10.1074/jbc.M011380200. PMID 11278895.
Ivings L, Pennington SR, Jenkins R, Weiss JL, Burgoyne RD (May 2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". The Biochemical Journal. 363 (Pt 3): 599–608. doi:10.1042/0264-6021:3630599. PMC 1222513. PMID 11964161.

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[refGRCh38Ensembl-1] ENSG00000232421, ENSG00000183311, ENSG00000224156, ENSG00000235067, ENSG00000232575, ENSG00000227739, ENSG00000229684 GRCh38: Ensembl release 89: ENSG00000196230, ENSG00000232421, ENSG00000183311, ENSG00000224156, ENSG00000235067, ENSG00000232575, ENSG00000227739, ENSG00000229684 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001525 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11504633-5] Crabtree DV, Ojima I, Geng X, Adler AJ (Aug 2001). "Tubulins in the primate retina: evidence that xanthophylls may be endogenous ligands for the paclitaxel-binding site". Bioorganic & Medicinal Chemistry. 9 (8): 1967–76. doi:10.1016/S0968-0896(01)00103-1. PMID 11504633.

[pmid8270253-6] Volz A, Weiss E, Trowsdale J, Ziegler A (Jan 1994). "Presence of an expressed beta-tubulin gene (TUBB) in the HLA class I region may provide the genetic basis for HLA-linked microtubule dysfunction". Human Genetics. 93 (1): 42–6. doi:10.1007/BF00218911. PMID 8270253. S2CID 7853030.

[entrez-7] "Entrez Gene: TUBB tubulin, beta".

[pmid12482968-8] Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968.

[pmid12966166-9] Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

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TUBB

Interactions

See also

References

Further reading