From Wikipedia, the free encyclopedia
E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene .[5] [6]
This gene encodes a nuclear protein which is involved in cell-cycle regulation . The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST -containing nuclear protein), and together they may play a role in tumorigenesis .[6]
References
^ a b c GRCh38: Ensembl release 89: ENSG00000147854 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024817 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun . 296 (3): 530–6. doi :10.1016/S0006-291X(02)00890-2 . PMID 12176013 .
^ a b "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2" .
Further reading
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7. doi :10.1101/gr.2596504 . PMC 528928 . PMID 15489334 .
Unoki M, Nishidate T, Nakamura Y (2004). "ICBP90, an E2F-1 target, recruits HDAC1 and binds to methyl-CpG through its SRA domain" . Oncogene . 23 (46): 7601–10. doi :10.1038/sj.onc.1208053 . PMID 15361834 .
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway" . Genome Res . 14 (7): 1324–32. doi :10.1101/gr.2334104 . PMC 442148 . PMID 15231748 .
Li Y, Mori T, Hata H, et al. (2004). "NIRF induces G1 arrest and associates with Cdk2". Biochem. Biophys. Res. Commun . 319 (2): 464–8. doi :10.1016/j.bbrc.2004.04.190 . PMID 15178429 .
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9" . Nature . 429 (6990): 369–74. doi :10.1038/nature02465 . PMC 2734081 . PMID 15164053 .
Mori T, Li Y, Hata H, Kochi H (2004). "NIRF is a ubiquitin ligase that is capable of ubiquitinating PCNP, a PEST-containing nuclear protein" . FEBS Lett . 557 (1–3): 209–14. doi :10.1016/S0014-5793(03)01495-9 . PMID 14741369 . S2CID 10006213 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5. doi :10.1038/ng1285 . PMID 14702039 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. doi :10.1073/pnas.242603899 . PMC 139241 . PMID 12477932 .