ACP2
ACP2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ACP2, acid phosphatase 2, lysosomal, LAP | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 171650; MGI: 87882; HomoloGene: 1217; GeneCards: ACP2; OMA:ACP2 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Lysosomal acid phosphatase is an enzyme that in humans is encoded by the ACP2 gene.[5][6]
Lysosomal acid phosphatase is composed of two subunits, alpha and beta, and is chemically and genetically distinct from red cell acid phosphatase. Lysosomal acid phosphatase 2 is a member of a family of distinct isoenzymes which hydrolyze orthophosphoric monoesters to alcohol and phosphate. Acid phosphatase deficiency is caused by mutations in the ACP2 (beta subunit) and ACP3 (alpha subunit) genes.[6]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000134575 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000002103 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Shows TB, Brown JA, Lalley PA (Dec 1976). "Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate dehydrogenase A genes on chromosome 11". Cytogenet Cell Genet. 16 (1–5): 231–4. doi:10.1159/000130598. PMID 975882.
- ^ a b "Entrez Gene: ACP2 acid phosphatase 2, lysosomal".
External links
- Human ACP2 genome location and ACP2 gene details page in the UCSC Genome Browser.
Further reading