AFF1

AFF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2LM0
Identifiers
Aliases	AFF1, AF4, MLLT2, PBM1, AF4/FMR2 family member 1
External IDs	OMIM: 159557; MGI: 1100819; HomoloGene: 4340; GeneCards: AFF1; OMA:AFF1 - orthologs
Gene location (Human)
Chr.	Chromosome 4 (human)
End	87,141,039 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	104,003,188 bp
RNA expression pattern
	Top expressed in
	Epithelium of choroid plexus; ; renal medulla; ; skin of hip; ; retinal pigment epithelium; ; tail of epididymis; ; trabecular bone; ; Skeletal muscle tissue of biceps brachii; ; seminal vesicula; ; caput epididymis; ; glutes;
	Top expressed in
	lacrimal gland; ; ciliary body; ; cumulus cell; ; retinal pigment epithelium; ; gastrula; ; vestibular membrane of cochlear duct; ; iris; ; Paneth cell; ; lobe of prostate; ; decidua;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA-binding transcription factor activity; protein binding; double-stranded DNA binding;
Cellular component	nucleus; transcription elongation factor complex; super elongation complex;
Biological process	regulation of transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	4299
	17355
	ENSG00000172493
	ENSMUSG00000029313
	P51825
	O88573
	NM_001313959; NM_001313960; NM_001166693; NM_005935
	NM_001080798; NM_133919
	NP_001160165; NP_001300888; NP_001300889; NP_005926
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

AF4/FMR2 family member 1 is a protein that in humans is encoded by the AFF1 gene.^[5]^[6]^[7]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172493 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029313 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Domer PH, Fakharzadeh SS, Chen CS, Jockel J, Johansen L, Silverman GA, Kersey JH, Korsmeyer SJ (Sep 1993). "Acute mixed-lineage leukemia t(4;11)(q21;q23) generates an MLL-AF4 fusion product". Proc Natl Acad Sci U S A. 90 (16): 7884–8. doi:10.1073/pnas.90.16.7884. PMC 47247. PMID 7689231.
^ Gu Y, Nakamura T, Alder H, Prasad R, Canaani O, Cimino G, Croce CM, Canaani E (Dec 1992). "The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene". Cell. 71 (4): 701–8. doi:10.1016/0092-8674(92)90603-A. PMID 1423625.
^ Chen CS, Hilden JM, Frestedt J, Domer PH, Moore R, Korsmeyer SJ, Kersey JH (Sep 1993). "The chromosome 4q21 gene (AF-4/FEL) is widely expressed in normal tissues and shows breakpoint diversity in t(4;11)(q21;q23) acute leukemia". Blood. 82 (4): 1080–5. PMID 8353274.
^ "Entrez Gene: AFF1 AF4/FMR2 family, member 1".

Human AFF1 genome location and AFF1 gene details page in the UCSC Genome Browser.