AGPAT9

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GPAT3
Identifiers
Aliases GPAT3, AGPAT 10, AGPAT8, LPAAT-theta, MAG1, AGPAT9, HMFN0839, AGPAT10, glycerol-3-phosphate acyltransferase 3
External IDs MGI: 3603816 HomoloGene: 13099 GeneCards: GPAT3
EC number 2.3.1.51
Gene location (Human)
Chromosome 4 (human)
Chr. Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for GPAT3
Genomic location for GPAT3
Band 4q21.23 Start 83,535,914 bp[1]
End 83,605,875 bp[1]
RNA expression pattern
PBB GE MAG1 gnf1h00899 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256421
NM_001256422
NM_032717

NM_172715

RefSeq (protein)

NP_001243350
NP_001243351
NP_116106

NP_766303

Location (UCSC) Chr 4: 83.54 – 83.61 Mb Chr 5: 100.85 – 100.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glycerol-3-phosphate acyltransferase 3 (GPAT-3) is an enzyme that in humans is encoded by the AGPAT9 gene.[5][6][7][8] GPAT-3 is also known as:

  • 1-acylglycerol-3-phosphate O-acyltransferase 9 (AGPAT9),
  • lysophosphatidic acid acyltransferase theta (LPAAT-theta), or
  • lung cancer metastasis-associated protein 1.

Function[edit]

Glycerol-3-phosphate (G3P) acyltransferases (GPAT; EC 2.3.1.15), such as GPAM and GPAT3 (this enzyme), catalyze the initial step of de novo triacylglycerol (TAG) synthesis by converting glycerol-3-phosphate (G3P) to lysophosphatidic acid (LPA).[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138678 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029314 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Clark HF, Gurney AL, Abaya E, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697Freely accessible. PMID 12975309. 
  6. ^ a b Cao J, Li JL, Li D, Tobin JF, Gimeno RE (December 2006). "Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis". Proc. Natl. Acad. Sci. U.S.A. 103 (52): 19695–700. doi:10.1073/pnas.0609140103. PMC 1702318Freely accessible. PMID 17170135. 
  7. ^ Tang W, Yuan J, Chen X, Gu X, Luo K, Li J, Wan B, Wang Y, Yu L (September 2006). "Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway". J. Biochem. Mol. Biol. 39 (5): 626–35. doi:10.5483/BMBRep.2006.39.5.626. PMID 17002884. 
  8. ^ "Entrez Gene: AGPAT9: 1-acylglycerol-3-phosphate O-acyltransferase 9". 

External links[edit]

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.