AKTIP

AKTIP
Identifiers
Aliases	AKTIP, FT1, FTS, AKT interacting protein
External IDs	OMIM: 608483; MGI: 3693832; HomoloGene: 7721; GeneCards: AKTIP; OMA:AKTIP - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	53,504,411 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	91,926,604 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pons; ; muscle of thigh; ; C1 segment; ; amniotic fluid; ; prefrontal cortex; ; amygdala; ; substantia nigra; ; anterior cingulate cortex; ; vastus lateralis muscle;
	Top expressed in
	right kidney; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; neural layer of retina; ; globus pallidus; ; central gray substance of midbrain; ; superior frontal gyrus; ; lateral hypothalamus; ; dorsomedial hypothalamic nucleus; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-like protein transferase activity; protein binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity;
Cellular component	HOPS complex; plasma membrane; membrane; FHF complex; cytosol; cytoplasm;
Biological process	protein transport; positive regulation of protein binding; positive regulation of protein phosphorylation; lysosome organization; early endosome to late endosome transport; endosome organization; endosome to lysosome transport; apoptotic process; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
	64400
	14339
	ENSG00000166971
	ENSMUSG00000031667
	Q9H8T0
	Q64362
	NM_001012398; NM_001308325; NM_022476
NM_010241; NM_001302266; NM_001302267; NM_001302268; NM_001302337;
	NM_001358934; NM_001358935; NM_001358936; NM_001358937; NM_001358938
	NP_001012398; NP_001295254; NP_071921
NP_001289195; NP_001289196; NP_001289197; NP_001289266; NP_034371;
	NP_001345863; NP_001345864; NP_001345865; NP_001345866; NP_001345867
	Wikidata
View/Edit Human	View/Edit Mouse

AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

AKTIP has been shown to interact with AKT1.^[8]

Molecular genetics

The association between the AKTIP gene variants in a sample of 273 bipolar patients using 3 single-nucleotide polymorphisms has been investigated. No association between suicidal behavior and AKTIP variants nor any interaction between AKTIP and AKT1 polymorphisms was observed.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000166971 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031667 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem Biophys Res Commun. 206 (1): 341–7. doi:10.1006/bbrc.1995.1047. PMID 7818539.
^ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (Jun 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: AKTIP AKT interacting protein".
^ Remy, Ingrid; Michnick Stephen W (Feb 2004). "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt". Mol. Cell. Biol. 24 (4). United States: 1493–504. doi:10.1128/MCB.24.4.1493-1504.2004. ISSN 0270-7306. PMC 344167. PMID 14749367. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help)
^ Magno LA, Miranda DM, Neves FS, Pimenta GJ, Mello MP, De Marco LA, Correa H, Romano-Silva MA (January 2010). "Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients". Genes Brain Behav. 9 (4): 411–8. doi:10.1111/j.1601-183X.2010.00571.x. PMID 20132317.

External links

Human AKTIP genome location and AKTIP gene details page in the UCSC Genome Browser.

Interactions

Molecular genetics

References

External links

Further reading